Evidence map›Paper›PMID 29686045›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Subthreshold Amyloid Predicts Tau Deposition in Aging.

Stephanie L Leal, Samuel N Lockhart, Anne Maass, Rachel K Bell, William J Jagust

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 138 citations in OpenAlex.

  1. Trial
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  4. Complex interplay of astrogliosis and pathology in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  5. Article
  6. Characterizing amyloid and tau positron emission tomography-based stages across the clinical continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
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  9. Review
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  16. Heterogeneous Functional Regression for Subgroup Analysis.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2024
    Article
  17. Article
  18. Article
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  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Stephanie L LealHelen Wills Neuroscience Institute, University of California, Berkeley, California 94720, stephanieleal@berkeley.edu.ORCID 0000-0002-8082-8291
Samuel N LockhartHelen Wills Neuroscience Institute, University of California, Berkeley, California 94720.ORCID 0000-0002-0893-5420
Anne MaassHelen Wills Neuroscience Institute, University of California, Berkeley, California 94720.
Rachel K BellHelen Wills Neuroscience Institute, University of California, Berkeley, California 94720.
William J JagustHelen Wills Neuroscience Institute, University of California, Berkeley, California 94720.ORCID 0000-0002-4458-113X
University of California, Berkeley · USGerman Center for Neurodegenerative Diseases · DELawrence Berkeley National Laboratory · USWake Forest University · US

Funding

Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BAKER, LAURA D. · 2016 to 2020
$12.2M
Neural and Biochemical Mechanisms of Cognitive AgingR01AG034570 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI William J. Jagust · 2009 to 2026
$12.0M
Effect of tau pathology on memory consolidation in cognitively normal agingF32AG054116 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI LEAL, STEPHANIE L. · 2016 to 2017
$112k
NIA NIH HHS F32 AG054116NIA NIH HHS P30 AG049638NIA NIH HHS R01 AG034570
6 · The paper itself

Abstract

Current approaches to the early detection of Alzheimer's disease (AD) rely upon classifying individuals as "positive" or "negative" for biomarkers related to the core pathology of β-amyloid (Aβ). However, the accumulation of Aβ begins slowly, years before biomarkers become abnormal. We used longitudinal [

Indexed as

AgedAged, 80 and overAgingAlzheimer DiseaseAmyloid beta-PeptidesAniline CompoundsBiomarkersCarbolinesCerebral CortexDisease ProgressionFemaleHumansMagnetic Resonance ImagingMaleMemory DisordersNeuropsychological Tests2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleAmyloid beta-PeptidesAniline CompoundsBiomarkersCarbolinesRadiopharmaceuticalstau ProteinsThiazolesagingamyloidmemoryPETpreclinicaltau

Identifiers

PMID29686045
PMCPMC5943976
OpenAlexW2801683790

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.