ArticleStroke2018
Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease: A Mendelian Randomization Analysis.
Article in Stroke, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 6 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Association between Type 2 Diabetes Mellitus and Brain Atrophy: A Meta-Analysis.Diabetes & metabolism journal · 2022Pooled it
- Association between fasting blood glucose levels and stroke events: a large-scale community-based cohort study from China.BMJ open · 2021Pooled it
- Impact of high glucose levels and glucose lowering on risk of ischaemic stroke: a Mendelian randomisation study and meta-analysis.Diabetologia · 2021Pooled it
- Causal associations of insulin resistance with coronary artery disease and ischemic stroke: a Mendelian randomization analysis.BMJ open diabetes research & care · 2020Pooled it
- Relationship Between Type 2 Diabetes and White Matter Hyperintensity: A Systematic Review.Frontiers in endocrinology · 2020Pooled it
- Characterization of White Matter Hyperintensities in Large-Scale MRI-Studies.Frontiers in neurology · 2019Pooled it
- Diabetic cerebral microvascular disorder: from key pathologies to targeted interventions.Annals of medicine · 2026Review
- Neurovascular dysfunction in cerebral small vessel disease: impact on cognition and depression using arterial spin labeling and resting-state fMRI.Brain imaging and behavior · 2026Article
- Antiplatelet Therapy for Stroke Prevention in Atherosclerotic Cardiovascular Disease-Naïve People with Cerebral Small-Vessel Disease: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Acute Ischemic Stroke as the Initial Presentation of Primary Sjögren's Syndrome: A Case Report.Cureus · 2026Article
- SELE is associated with reduced breast cancer susceptibility: Evidence from Mendelian randomization and single-cell transcriptome.Translational oncology · 2026Article
- Association between minimum nocturnal heart rate and cerebral small vessel disease in patients with obstructive sleep apnea.Frontiers in aging neuroscience · 2026Article
- Type 2 Diabetes Mellitus, Cognitive Performance, and Incident Dementia; Identifying Mediating Pathways and Biomarkers From the Plasma Proteome.Journal of neurochemistry · 2025Article
- Practical limitations of complex insulin therapies in type 2 diabetes: Focus on therapy simplification using fixed-ratio combinations of basal insulin and a glucagon-like peptide-1 receptor agonist.Diabetes, obesity & metabolism · 2025Review
- Association Between Pre-Admission ATRIA Scores and Initial Stroke Severity in Acute Ischemic Stroke: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Endothelial cells as key players in cerebral small vessel disease.Nature reviews. Neuroscience · 2025Review
- Association Between Triglyceride-Glucose Index and Carotid Plaque Stability in Different Glycemic Status: A Single-Center Retrospective Study.Journal of the American Heart Association · 2025Article
- Review of the mechanism of infection induced cerebral small vessel disease.Frontiers in immunology · 2025Review
- Cerebral perfusion and gray matter volume alterations associated with cognitive impairment in metabolic syndrome with cerebral small vessel disease.Frontiers in aging neuroscience · 2025Article
- Sustained high Life's Essential 8 is associated with lower risk of cerebral small vessel disease: a community-based study.Frontiers in neurology · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
background and purposeThe relationship between type 2 diabetes mellitus (T2D) and cerebral small vessel disease (CSVD) is unclear. We aimed to examine the causal effect of T2D, fasting glucose levels, and higher insulin resistance on CSVD using Mendelian randomization.
methodsFive CSVD phenotypes were studied; 2 were clinical outcomes associated with CSVD (lacunar stroke: n=2191/27 297 and intracerebral hemorrhage [ICH]: n=2254/8195 [deep and lobar ICH]), whereas 3 were radiological markers of CSVD (white matter hyperintensities: n=8429; fractional anisotropy [FA]: n=8357; and mean diffusivity: n=8357). We applied 2 complementary analyses to evaluate the association of T2D with CSVD. First, we used summarized data from genome-wide association study to calculate the effects of T2D-related variants on CSVD with inverse-variance weighted and weighted median approaches. Second, we performed a genetic risk score approach to test the effects of T2D-associated variants on white matter hyperintensities, FA, and mean diffusivity using individual-level data in UK Biobank.
resultsT2D was associated with higher risk of lacunar stroke (odds ratio [OR], 1.15; 95% confidence interval [CI], 1.04-1.28;
conclusionsOur Mendelian randomization study provides evidence to suggest that T2D may be causally associated with CSVD, in particular with lacunar stroke and FA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.