Evidence map›Paper›PMID 29686012›Full record

ArticleHypertension (Dallas, Tex. : 1979)2018

Neuronal Suppressor of Cytokine Signaling 3: Role in Modulating Chronic Metabolic and Cardiovascular Effects of Leptin.

Jussara M do Carmo, Alexandre A da Silva, John Nathan Freeman, Zhen Wang, Sydney P Moak, Michael W Hankins, Heather A Drummond, John E Hall

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jussara M do CarmoFrom the Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson (J.M.d.C., A.A.d.S., J.N.F., Z.W., S.P.M., M.W.H., H.A.D., J.E.H.) jdocarmo@umc.edu.
Alexandre A da SilvaFrom the Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson (J.M.d.C., A.A.d.S., J.N.F., Z.W., S.P.M., M.W.H., H.A.D., J.E.H.).
John Nathan FreemanFrom the Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson (J.M.d.C., A.A.d.S., J.N.F., Z.W., S.P.M., M.W.H., H.A.D., J.E.H.).
Zhen WangFrom the Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson (J.M.d.C., A.A.d.S., J.N.F., Z.W., S.P.M., M.W.H., H.A.D., J.E.H.).
Sydney P MoakFrom the Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson (J.M.d.C., A.A.d.S., J.N.F., Z.W., S.P.M., M.W.H., H.A.D., J.E.H.).
Michael W HankinsFrom the Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson (J.M.d.C., A.A.d.S., J.N.F., Z.W., S.P.M., M.W.H., H.A.D., J.E.H.).
Heather A DrummondFrom the Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson (J.M.d.C., A.A.d.S., J.N.F., Z.W., S.P.M., M.W.H., H.A.D., J.E.H.).
John E HallFrom the Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson (J.M.d.C., A.A.d.S., J.N.F., Z.W., S.P.M., M.W.H., H.A.D., J.E.H.).
University of Mississippi Medical Center · USCentro Universitário Barão de Mauá · BR

Funding

STRUCTURAL VASCULAR ADAPTATION OF THE MICROCIRCULATIONP01HL051971 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI HALL, JOHN E · 1993 to 2018
$39.4M
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Babbette LaMarca, Jane F Reckelhoff · 2017 to 2026
$26.4M
The role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4M
NHLBI NIH HHS P01 HL051971NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P20 GM121334NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

We determined whether deficiency of neuronal SOCS3 (suppressor of cytokine signaling 3)-a potential negative regulator of leptin signaling-amplifies the chronic effects of leptin on food intake, energy expenditure, glucose, and blood pressure (BP) and protects against adverse cardiometabolic effects of obesity. BP and heart rate were recorded by telemetry, and oxygen consumption (VO

Indexed as

AnimalsBlood PressureBody WeightDisease Models, AnimalFemaleLeptinMaleMetabolic SyndromeMiceNeuronsOxygen ConsumptionSignal TransductionSuppressor of Cytokine Signaling 3 ProteinLeptinSocs3 protein, mouseSuppressor of Cytokine Signaling 3 Proteinappetiteblood pressureheart ratehypertensionobesity

Identifiers

PMID29686012
PMCPMC5945310
OpenAlexW2803048764

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.