Evidence map›Paper›PMID 29685986›Full record

ArticleInfection and immunity2018

Glucan Binding Protein C of Streptococcus mutans Mediates both Sucrose-Independent and Sucrose-Dependent Adherence.

Joshua L Mieher, Matthew R Larson, Norbert Schormann, Sangeetha Purushotham, Ren Wu, Kanagalaghatta R Rajashankar, Hui Wu, Champion Deivanayagam

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Review
  3. TargetingACS medicinal chemistry letters · 2026
    Article
  4. Article
  5. Article
  6. The structure ofInfection and immunity · 2026
    Article
  7. Article
  8. Frontiers in cellular and infection microbiology · 2026
    Article
  9. Review
  10. Article
  11. Virtual Screening of Inhibitors ofACS medicinal chemistry letters · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. The catalytic domains of Streptococcus mutans glucosyltransferases: a structural analysis.Acta crystallographica. Section F, Structural biology communications · 2023
    Article
  16. Review
  17. Review
  18. Formation of Biofilm byFrontiers in microbiology · 2022
    Article
  19. Inhibition ofJournal of oral microbiology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joshua L Mieher *Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Matthew R Larson *Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Norbert SchormannDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Sangeetha PurushothamDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Ren WuPediatric Dentistry and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Kanagalaghatta R RajashankarDepartment of Chemistry and Chemical Biology, Cornell University, NE-CAT, Advanced Photon Source, Argonne, Illinois, USA.
Hui WuPediatric Dentistry and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Champion DeivanayagamDepartment of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA champy@uab.edu.
University of Alabama at Birmingham · USCornell University · US

Funding

Y-FAMILY POLYMERASES AND CO-FACTORS IN TRANSLESION REPLICATIONP41RR015301 · NCRR · CORNELL UNIVERSITY ITHACA · PI EISENBERG, DAVID · 2001 to 2011
$28.2M
Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
Dental Academic Research Training Program (DART)T90DE022736 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Amjad Javed · 2012 to 2026
$6.7M
Glycosylation & Function of an Oral Streptococcal AdhesinR01DE017954 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WU, HUI · 2007 to 2022
$5.8M
SMALL MOLECULE INHIBITORS OF CARIOGENIC BIOFILMSR01DE022350 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Christian Corey Melander, Hui Wu · 2012 to 2026
$4.3M
Determination of the SAG Binding Motif on AgI/II of Streptococcus MutansR01DE017737 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEIVANAYAGAM, CHAMPION CHRISTDOSS SELVAKUMAR · 2007 to 2011
$1.8M
Structural and Functional Studies on the Platelet Adherence Protein A of StreptocR21AI105038 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEIVANAYAGAM, CHAMPION CHRISTDOSS SELVAKUMAR · 2014 to 2015
$404k
NCRR NIH HHS P41 RR015301NIAID NIH HHS R21 AI105038NIDCR NIH HHS R01 DE017737NIDCR NIH HHS R01 DE017954NIDCR NIH HHS R01 DE022350NIDCR NIH HHS T90 DE022736NIGMS NIH HHS P41 GM103403
6 · The paper itself

Abstract

The high-resolution structure of glucan binding protein C (GbpC) at 1.14 Å, a sucrose-dependent virulence factor of the dental caries pathogen

Indexed as

Bacterial AdhesionBiofilmsCalcium-Binding ProteinsCarrier ProteinsCrystallographyDextransDNA-Binding ProteinsLectinsReceptors, Cell SurfaceReceptors, ScavengerStreptococcus mutansSucroseTumor Suppressor ProteinsCalcium-Binding ProteinsCarrier ProteinsDextransDMBT1 protein, humanDNA-Binding Proteinsglucan-binding proteinsLectinsReceptors, Cell SurfaceReceptors, ScavengerSucroseTumor Suppressor Proteinsantigen I/IIfibrillarglucan binding proteinlectin-like foldmicrobial adherencepolyproline type II helixsalivary agglutininStreptococcus gordoniiStreptococcus mutanssucrose-dependent adhesionsucrose-independent adhesion

Identifiers

PMID29685986
PMCPMC6013656
OpenAlexW2800838243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.