Evidence map›Paper›PMID 29685931›Full record

ArticleCirculation2018

miR-22 in Smooth Muscle Cells: A Potential Therapy for Cardiovascular Disease.

Zhan-Peng Huang, Da-Zhi Wang

Abstract readEditorialComment
In one paragraph

Article in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. The role of microRNAs in calcific aortic valve disease.Frontiers in cardiovascular medicine · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Loss ofeLife · 2021
    Article
  13. Review
  14. Liver research (Beijing, China) · 2020
    Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Zhan-Peng HuangCenter for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China (Z.-P.H.). huangzhp27@mail.sysu.edu.cn dwang@enders.tch.harvard.edu.
Da-Zhi WangDepartment of Cardiology, Boston Children's Hospital, Harvard Medical School, MA (Z.-P.H., D.-Z.W.).

Funding

RESEARCH METHODS IN PEDIATRICS HEART DISEASET32HL007572 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI Sarah D DE FERRANTI, Jane W. Newburger · 1985 to 2026
$13.0M
MicroRNAs, cardiac development and functionR01HL085635 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WANG, DA-ZHI · 2007 to 2015
$3.2M
MicroRNAs, cardiac function and cardiomyopathyR01HL138757 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI WANG, DA-ZHI · 2017 to 2020
$2.1M
Therapeutic applications of miRNAs in myocardial and cardiac regenerationR01HL125925 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI WANG, DA-ZHI · 2016 to 2019
$1.8M
Molecular Mechanisms of Dilated CardiomyopathyR01HL116919 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI WANG, DA-ZHI · 2013 to 2016
$1.7M
NHLBI NIH HHS R01 HL085635NHLBI NIH HHS R01 HL116919NHLBI NIH HHS R01 HL125925NHLBI NIH HHS R01 HL138757
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cardiovascular DiseasesMicroRNAsHumansMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaMicroRNAsMIRN22 microRNA, humancardiovascular diseaseEditorialsgene regulationgene therapymicroRNAnon-coding RNAsmooth musclevascular smooth muscle

Identifiers

PMID29685931
PMCPMC5918419

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.