Evidence map›Paper›PMID 29685891›Full record

ArticleThe Journal of biological chemistry2018

Cytotoxic and mutagenic properties of minor-groove

Jun Wu, Pengcheng Wang, Lin Li, Changjun You, Yinsheng Wang

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Metabolic Activation and DNA Interactions of CarcinogenicInternational journal of molecular sciences · 2022
    Review
  5. Article
  6. Article
  7. The roles of polymerases ν and θ in replicative bypass ofThe Journal of biological chemistry · 2020
    Article
  8. Article
  9. The Impact of Minor-GrooveACS chemical biology · 2019
    Article
  10. Repair and translesion synthesis ofThe Journal of biological chemistry · 2019
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jun WuFrom the Department of Chemistry and.
Pengcheng WangEnvironmental Toxicology Graduate Program, University of California, Riverside, California 92521-0403.
Lin LiFrom the Department of Chemistry and.
Changjun YouFrom the Department of Chemistry and.
Yinsheng WangFrom the Department of Chemistry and Yinsheng.Wang@ucr.edu.

Funding

Repair and Biological Consequences of Alkylated Thymidine LesionsR01ES025121 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI WANG, YINSHENG · 2015 to 2019
$2.2M
NIEHS NIH HHS R01 ES025121
6 · The paper itself

Abstract

Endogenous metabolism, environmental exposure, and cancer chemotherapy can lead to alkylation of DNA. It has been well documented that, among the different DNA alkylation products, minor-groove

Indexed as

DNA DamageDNA ReplicationAlkylationCRISPR-Cas SystemsDNADNA-Directed DNA PolymeraseGene EditingHEK293 CellsHumansMutagenesisThymidineDNADNA-Directed DNA PolymeraseThymidinealkylating agentDNA adductDNA alkylationDNA damageDNA polymeraseDNA replicationmutagenesismutagenesis mechanismO2-alkylthymidinepolymerasetranslesion synthesistranslesion synthesis polymerase

Identifiers

PMID29685891
PMCPMC5986211

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.