Evidence map›Paper›PMID 29685876›Full record

ReviewBMJ (Clinical research ed.)2018

Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications.

Bryant R England, Geoffrey M Thiele, Daniel R Anderson, Ted R Mikuls

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMJ (Clinical research ed.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 291 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
291citing papers in PubMed, 11 pooled it
33.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

291 citing papers in PubMed, 11 syntheses or guidelines pooled it, 590 citations in OpenAlex.

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231 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Bryant R EnglandVeterans Affairs (VA) Nebraska-Western Iowa Health Care System, Omaha, NE, USA.
Geoffrey M ThieleVeterans Affairs (VA) Nebraska-Western Iowa Health Care System, Omaha, NE, USA.
Daniel R AndersonDivision of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Ted R MikulsVeterans Affairs (VA) Nebraska-Western Iowa Health Care System, Omaha, NE, USA tmikuls@unmc.edu.
University of Nebraska Medical Center · USVA Nebraska Western Iowa Health Care System · US

Funding

Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GUDA, CHITTIBABU · 2016 to 2025
$42.8M
The Effects of Urate Lowering Therapy on Inflammation, Endothelial function, andP50AR060772 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SINGH, JASVINDER A · 2012 to 2021
$12.8M
UNMC Summer Undergraduate Alcohol Research ProgramR25AA020818 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Kristina L Bailey · 2012 to 2026
$931k
NIAAA NIH HHS R25 AA020818NIAMS NIH HHS P50 AR060772NIGMS NIH HHS U54 GM115458
6 · The paper itself

Abstract

Rheumatoid arthritis is a systemic autoimmune disease characterized by excess morbidity and mortality from cardiovascular disease. Mechanisms linking rheumatoid arthritis and cardiovascular disease include shared inflammatory mediators, post-translational modifications of peptides/proteins and subsequent immune responses, alterations in the composition and function of lipoproteins, increased oxidative stress, and endothelial dysfunction. Despite a growing understanding of these mechanisms and their complex interplay with conventional cardiovascular risk factors, optimal approaches of risk stratification, prevention, and treatment in the context of rheumatoid arthritis remain unknown. A multifaceted approach to reduce the burden posed by cardiovascular disease requires optimal management of traditional risk factors in addition to those intrinsic to rheumatoid arthritis such as increased disease activity. Treatments for rheumatoid arthritis seem to exert differential effects on cardiovascular risk as well as the mechanisms linking these conditions. More research is needed to establish whether preferential rheumatoid arthritis therapies exist in terms of prevention of cardiovascular disease. Ultimately, understanding the unique mechanisms for cardiovascular disease in rheumatoid arthritis will aid in risk stratification and the identification of novel targets for meaningful reduction of cardiovascular risk in this patient population.

Indexed as

Arthritis, RheumatoidCardiovascular DiseasesPatient Care ManagementAutoimmunityHumansRisk AssessmentRisk Factors

Identifiers

PMID29685876
PMCPMC6889899
OpenAlexW2800826112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.