ArticleHeart, lung & circulation2019
Homocysteine and Incident Atrial Fibrillation: The Atherosclerosis Risk in Communities Study and the Multi-Ethnic Study of Atherosclerosis.
Article in Heart, lung & circulation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Research on left atrial appendage thrombogenic milieu prediction model in patients with nonvalvular atrial fibrillation based on machine learning algorithm.BMC cardiovascular disorders · 2025Article
- The relationship between homocysteine and new-onset atrial fibrillation in patients with acute myocardial infarction.Annals of medicine · 2025Article
- Common Methylenetetrahydrofolate Reductase PolymorphismDiagnostics (Basel, Switzerland) · 2025Article
- Differential impact of lipid levels on the association between homocysteine and new-onset atrial fibrillation in acute myocardial infarction patients.European journal of medical research · 2025Article
- Plasma homocysteine levels and risk of congestive heart failure or cardiomyopathy: A Mendelian randomization study.Frontiers in cardiovascular medicine · 2023Article
- Homocysteine as a Predictor of Paroxysmal Atrial Fibrillation-Related Events: A Scoping Review of the Literature.Diagnostics (Basel, Switzerland) · 2022Article
- Serum Homocysteine Level Predictive Capability for Severity of Restenosis Post Percutaneous Coronary Intervention.Frontiers in pharmacology · 2022Article
- Lipoprotein (a) and coronary artery calcification: prospective study assessing interactions with other risk factors.Metabolism: clinical and experimental · 2021Article
- Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study.Clinical chemistry · 2021Article
- Appraising the Causal Association of Plasma Homocysteine Levels With Atrial Fibrillation Risk: A Two-Sample Mendelian Randomization Study.Frontiers in genetics · 2021Article
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- Association Between Homocysteine and Vascular Calcification Incidence, Prevalence, and Progression in the MESA Cohort.Journal of the American Heart Association · 2020Article
- Vitamin BBMJ open · 2019Article
- Vascular inflammation, atherosclerosis, and lipid metabolism and the occurrence of non-high albuminuria diabetic kidney disease: A cross-sectional study.Diabetes & vascular disease researchArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAlthough many studies have investigated the association of blood homocysteine with major cardiovascular diseases such as coronary heart disease and stroke, research on its association with atrial fibrillation (AF) is scarce.
methodsWe analysed data from Atherosclerosis Risk in Communities (ARIC) Study (n=492, age 45-64 years) and Multi-Ethnic Study of Atherosclerosis (MESA) (n=6,641, age 45-84 years).
resultsDuring the 10,106 and 67,613 person-years of follow-up, we identified 85 and 351 AF events in ARIC and MESA, respectively. An age-, sex-, and race-adjusted model showed dose-response relations between plasma homocysteine concentrations and AF incidence in both ARIC and MESA. Further adjustments for other AF risk factors did not change the associations. In the fully adjusted model, a meta-analysis of both studies showed a significant association between homocysteine and AF [hazard ratio (95% confidence interval) per 1 unit increment in log
conclusionsIn the prospective population-based ARIC and MESA cohorts, elevated homocysteine was modestly associated with an increased risk of incident AF, but the C6
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