Evidence map›Paper›PMID 29685480›Full record

Observational studyJournal of diabetes and its complications2018

Mortality in youth-onset type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth study.

Kristi Reynolds, Sharon H Saydah, Scott Isom, Jasmin Divers, Jean M Lawrence, Dana Dabelea, Elizabeth J Mayer-Davis, Giuseppina Imperatore, Ronny A Bell, Richard F Hamman

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Journal of diabetes and its complications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  17. Treatment strategy for children and adolescents with type 2 diabetes-based on ISPAD Clinical Practice Consensus Guidelines 2022.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kristi ReynoldsDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, United States. Electronic address: Kristi.Reynolds@kp.org.
Sharon H SaydahDivision of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, United States. Electronic address: zle0@cdc.gov.
Scott IsomDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, United States. Electronic address: sisom@wakehealth.edu.
Jasmin DiversDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, United States. Electronic address: jdivers@wakehealth.edu.
Jean M LawrenceDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, United States. Electronic address: Jean.M.Lawrence@kp.org.
Dana DabeleaDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, United States. Electronic address: Dana.Dabelea@ucdenver.edu.
Elizabeth J Mayer-DavisDepartment of Nutrition, University of North Carolina, Chapel Hill, NC, United States; Department of Medicine, University of North Carolina, Chapel Hill, NC, United States. Electronic address: mayerdav@email.unc.edu.
Giuseppina ImperatoreDivision of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, United States. Electronic address: gai5@cdc.gov.
Ronny A BellDepartment of Public Health, East Carolina University, Greenville, NC, United States. Electronic address: bellr16@ecu.edu.
Richard F HammanDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, United States. Electronic address: Richard.Hamman@ucdenver.edu.

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6M
Colorado Clinical and Translational Science Institute (UL1)UL1TR000154 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2012 to 2013
$20.4M
Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4)SEARCH for Diabetes in Youth Cohort StudyUC4DK108173 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAGOSTINO, RALPH B. · 2015 to 2016
$14.8M
UCHSC DIABETES ENDOCRINOLOGY RESEARCH CENTERP30DK057516 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI HUTTON, JOHN C · 2000 to 2010
$14.0M
SEARCH for Diabetes in Youth Coordinating CenterU01DP000250 · DP · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BELL, RONNY A · 2005 to 2009
$4.8M
Population-based Diabetes Youth RegistryU18DP006131 · DP · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E · 2015 to 2019
$3.8M
SEARCH for Diabetes in Youth, Phase 3: Registry Study - Colorado CenterU18DP003256 · DP · UNIVERSITY OF COLORADO DENVER · PI DABELEA, DANA · 2010 to 2014
$3.6M
SEARCH For Diabetes in Youth, Phase 3: Cohort Study-Carolina CenterU18DP002708 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAYER-DAVIS, ELIZABETH J · 2010 to 2014
$3.6M
ACL HHS U18DP006131ACL HHS U18DP006133ACL HHS U18DP006134ACL HHS U18DP006136ACL HHS U18DP006138ACL HHS U18DP006139EPA EP-C-15-002NCATS NIH HHS UL1 TR000154NCATS NIH HHS UL1 TR000423NCATS NIH HHS UL1 TR001425NCATS NIH HHS UL1 TR001450NCATS NIH HHS UL1 TR002319NCCDPHP CDC HHS U01 DP000244NCCDPHP CDC HHS U01 DP000246NCCDPHP CDC HHS U01 DP000247NCCDPHP CDC HHS U01 DP000248NCCDPHP CDC HHS U01 DP000250NCCDPHP CDC HHS U01 DP000254NCCDPHP CDC HHS U18 DP002708NCCDPHP CDC HHS U18 DP002709NCCDPHP CDC HHS U18 DP002710NCCDPHP CDC HHS U18 DP002714NCCDPHP CDC HHS U18 DP003256NCCDPHP CDC HHS U18 DP006131NCCDPHP CDC HHS U18 DP006133NCCDPHP CDC HHS U18 DP006134NCCDPHP CDC HHS U18 DP006136NCCDPHP CDC HHS U18 DP006138NCCDPHP CDC HHS U18 DP006139NIDDK NIH HHS P30 DK056350NIDDK NIH HHS P30 DK057516NIDDK NIH HHS UC4 DK108173
6 · The paper itself

Abstract

aimsTo estimate short-term mortality rates for individuals with type 1 or type 2 diabetes diagnosed before age 20 years from the SEARCH for Diabetes in Youth study.

methodsWe included 8358 individuals newly-diagnosed with type 1 (n = 6840) or type 2 (n = 1518) diabetes from 1/1/2002-12/31/2008. We searched the National Death Index through 12/31/2010. We calculated standardized mortality ratios (SMRs) based on age, sex, and race for the comparable US population in the geographic areas of the SEARCH study.

resultsDuring 44,893 person-years (PY) of observation (median follow-up = 5.3 years), 41 individuals died (91.3 deaths/100,000 PY); 26 with type 1 (70.6 deaths/100,000 PY) and 15 with type 2 (185.6 deaths/100,000 PY) diabetes. The expected mortality rate was 70.9 deaths/100,000 PY. The overall SMR (95% CI) was 1.3 (1.0, 1.8) and was high among individuals with type 2 diabetes 2.4 (1.3, 3.9), females 2.2 (1.3, 3.3), 15-19 year olds 2.7 (1.7,4.0), and non-Hispanic blacks 2.1 (1.2, 3.4).

conclusionsCompared to the state populations of similar age, sex, and race, our results show excess mortality in individuals with type 2 diabetes, females, older youth, and non-Hispanic blacks. We did not observe excess short-term mortality in individuals with type 1 diabetes.

Indexed as

AdolescentAdultAge of OnsetChildChild, PreschoolDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHumansInfantInfant, NewbornLongitudinal StudiesMaleUnited StatesYoung AdultEpidemiologyMortalityType 1 DiabetesType 2 DiabetesYouth

Identifiers

PMID29685480
PMCPMC6089078

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.