Evidence map›Paper›PMID 29685167›Full record

ArticleJournal of medical case reports2018

Neutropenia caused by hairy cell leukemia in a patient with myelofibrosis secondary to polycythemia vera: a case report.

Andreas Hanssønn Habberstad, Hoa Thi Tuyet Tran, Ulla Randen, Signe Spetalen, Ingunn Dybedal, Geir E Tjønnfjord, Anders Erik Astrup Dahm

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Andreas Hanssønn HabberstadDepartment of Haematology, Akershus University Hospital, Lørenskog, Norway.
Hoa Thi Tuyet TranDepartment of Haematology, Akershus University Hospital, Lørenskog, Norway.
Ulla RandenDepartment of Pathology, Akershus University Hospital, Lørenskog, Norway.
Signe SpetalenDepartment of Pathology, Oslo University Hospital, Oslo, Norway.
Ingunn DybedalDepartment of Haematology, Oslo University Hospital, Oslo, Norway.
Geir E TjønnfjordDepartment of Haematology, Oslo University Hospital, Oslo, Norway.
Anders Erik Astrup DahmDepartment of Haematology, Akershus University Hospital, Lørenskog, Norway. aeadahm@gmail.com.
Akershus University Hospital · NOOslo University Hospital · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPolycythemia vera is a myeloproliferative disease that sometimes evolves to myelofibrosis, causing splenomegaly and neutropenia. In this case report, we describe a patient with polycythemia vera and unexplained neutropenia who later turned out to also have hairy cell leukemia. CASE PRESENTATION: A middle-aged Caucasian man with polycythemia vera presented to our hospital with chronic mouth ulcers. Later he developed leukopenia and pancytopenia. Bone marrow biopsies showed fibrosis. Further morphological analyses of bone marrow and blood smears revealed probable transformation into acute myeloid leukemia. However, there were also cells indicating hairy cell leukemia. Morphological and immunohistochemical analyses later confirmed the presence of hairy cell leukemia in biopsies that had been present for 3 years. Treatment with cladribine temporarily reversed the patient's neutropenia.

conclusionsHairy cell leukemia may mimic development to myelofibrosis in patients with polycythemia vera.

Indexed as

AgedAntineoplastic AgentsBiomarkers, TumorBone MarrowCladribineDisease ProgressionFatal OutcomeHumansJanus Kinase 2Leukemia, Hairy CellLeukemia, Myeloid, AcuteLeukopeniaMaleNeutropeniaOral UlcerPolycythemia VeraAntineoplastic AgentsBiomarkers, TumorCladribineJanus Kinase 2Case reportHairy cell leukemiaMyelofibrosisMyeloproliferative disordersNeutropeniaOral ulcerPolycythemia vera

Identifiers

PMID29685167
PMCPMC5914053
OpenAlexW2801321201

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.