ArticleKorean journal of anesthesiology2018
Effects of nefopam on catheter-related bladder discomfort in patients undergoing ureteroscopic litholapaxy.
Article in Korean journal of anesthesiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- The systematic review and meta-analysis evaluated the efficacy and safety of nefopam for catheter-related bladder discomfort based on randomized controlled trials.Frontiers in pharmacology · 2023Pooled it
- Different interventions for preventing postoperative catheter-related bladder discomfort: a systematic review and meta-analysis.European journal of clinical pharmacology · 2022Pooled it
- Buccal Acupuncture for Early Postoperative Catheter-Related Bladder Discomfort Following Ureteroscopic Lithotripsy: A Randomized, Sham-Controlled Trial.Journal of pain research · 2026Trial
- Esketamine for Preventing Catheter-Related Bladder Discomfort After Ureteroscopic Lithotripsy: A Randomized Controlled Trial.BMC anesthesiology · 2025Trial
- Effects of dexamethasone on catheter-related bladder discomfort and emergence agitation: a prospective, randomized, controlled trial.Korean journal of anesthesiology · 2022Trial
- Dose-Dependent Efficacy of Nefopam for Preventing Catheter-Related Bladder Discomfort in Patients Undergoing Transurethral Ureteroscopic Lithotripsy: A Retrospective Case-Control Observational Study.Journal of clinical medicine · 2026Article
- Efficacy and safety of an improved Xiao-Xu-Ming-Tang traditional Chinese medicine hot compress for preventing catheter-related bladder discomfort: a multicenter, randomized, double-blind, controlled trial.Frontiers in medicine · 2026Article
- Comparison of tramadol and lornoxicam for the prevention of postoperative catheter-related bladder discomfort: a randomized controlled trial.Perioperative medicine (London, England) · 2023Article
- Analgesic Efficacy of Nefopam as an Adjuvant in Patient-Controlled Analgesia for Acute Postoperative Pain After Laparoscopic Colorectal Cancer Surgery.Journal of clinical medicine · 2021Article
- Anesthetic considerations for urologic surgeries.Korean journal of anesthesiology · 2020Review
- Effects of Intraoperative Nefopam on Catheter-Related Bladder Discomfort in Patients Undergoing Robotic Nephrectomy: A Randomized Double-Blind Study.Journal of clinical medicine · 2019Article
- For the peace of postanesthesia care unit.Korean journal of anesthesiology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients who undergo urinary catheterization may experience postoperative catheter-related bladder discomfort (CRBD). Previous studies have indicated that drugs with antimuscarinic effects could reduce the incidence and severity of CRBD. Accordingly, this study was carried out to investigate whether nefopam, a centrally acting analgesic with concomitant antimuscarinic effect, reduces the incidence and severity of CRBD.
methodsSixty patients with American Society of Anesthesiologists physical status I and II and aged 18-70 years who were scheduled to undergo elective ureteroscopic litholapaxy participated in this double-blinded study. Patients were divided into control and nefopam groups, comprising 30 patients each. In the nefopam group, 40 mg nefopam in 100 ml of 0.9% saline was administered intravenously. In the control group, only 100 ml of 0.9% saline was administered. All patients had a urethral catheter and ureter stent inserted during surgery. The incidence and severity of CRBD, numerical rating scale (NRS) score of postoperative pain, rescue pethidine dose, and side effects were recorded in the post-anesthesia care unit after surgery.
resultsThe incidence (P = 0.020) and severity (P < 0.001) of CRBD were significantly different between the control group and the nefopam group. The NRS score of postoperative pain (P = 0.006) and rescue dose of pethidine (P < 0.001) were significantly higher in the control group than in the nefopam group.
conclusionsIntravenous administration of nefopam in patients scheduled to undergo ureteroscopic litholapaxy reduced the incidence and severity of CRBD, NRS score of postoperative pain and analgesic requirements.
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