Evidence map›Paper›PMID 29684787›Full record

ReviewCurrent opinion in biotechnology2018

The body electric 2.0: recent advances in developmental bioelectricity for regenerative and synthetic bioengineering.

Juanita Mathews, Michael Levin

Abstract readReview
In one paragraph

Review in Current opinion in biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Heuristically Adaptive Diffusion-Model Evolutionary Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. The Science of Tai Chi andJournal of integrative and complementary medicine · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Optical Estimation of Bioelectric Patterns in Living Embryos.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Juanita MathewsBiology Department, and Allen Discovery Center at Tufts University, Medford, MA 02155, United States.
Michael LevinBiology Department, and Allen Discovery Center at Tufts University, Medford, MA 02155, United States. Electronic address: michael.levin@tufts.edu.

Funding

Electrotherapeutic strategies for connective tissue repairR01AR061988 · NIAMS · TUFTS UNIVERSITY MEDFORD · PI HUNG, CLARK T., KAPLAN, DAVID L. · 2011 to 2015
$3.3M
Tissue Regeneration by Biophysical SignalingR01AR055993 · NIAMS · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L., LEVIN, MICHAEL · 2010 to 2018
$3.2M
NIAMS NIH HHS R01 AR055993NIAMS NIH HHS R01 AR061988
6 · The paper itself

Abstract

Breakthroughs in biomedicine and synthetic bioengineering require predictive, rational control over anatomical structure and function. Recent successes in manipulating cellular and molecular hardware have not been matched by progress in understanding the patterning software implemented during embryogenesis and regeneration. A fundamental capability gap is driving desired changes in growth and form to address birth defects and traumatic injury. Here we review new tools, results, and conceptual advances in an exciting emerging field: endogenous non-neural bioelectric signaling, which enables cellular collectives to make global decisions and implement large-scale pattern homeostasis. Spatially distributed electric circuits regulate gene expression, organ morphogenesis, and body-wide axial patterning. Developmental bioelectricity facilitates the interface to organ-level modular control points that direct patterning in vivo. Cracking the bioelectric code will enable transformative progress in bioengineering and regenerative medicine.

Indexed as

ElectricityElectrophysiological PhenomenaAnimalsBioengineeringBiological EvolutionHumansModels, BiologicalRegenerative Medicine

Identifiers

PMID29684787
PMCPMC10464502

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.