ArticleThe journal of allergy and clinical immunology. In practice
Exposure and Sensitization to Pets Modify Endotoxin Association with Asthma and Wheeze.
Article in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Indoor allergen exposure in relation to sleep health among US adults.The journal of allergy and clinical immunology. Global · 2025Article
- Pets and related allergens modify the association between early life DEHP exposure and respiratory outcomes in children.Environmental research · 2025Article
- Joint association of indoor allergens, endotoxins, heavy metals, and parabens with allergy-related outcomes in U. S. adults.Frontiers in public health · 2025Article
- Association Between Pet Keeping and Current Asthma Among Adolescents Living in Yazd; Evidence from Global Asthma Network (GAN) 2020 Cross-sectional Study.Archives of Iranian medicine · 2023Article
- Relationship between Food Allergy and Endotoxin Concentration and the Toleration Status at 2 Years: The Japan Environment and Children's Study.Nutrients · 2023Article
- Environmental allergen reduction in asthma management: an overview.Frontiers in allergy · 2023Review
- Exposure levels of animal allergens, endotoxin, and β-(1,3)-glucan on a university campus of veterinary medicine.PloS one · 2023Article
- Recombinant multimeric dog allergen prevents airway hyperresponsiveness in a model of asthma marked by vigorous TAllergy · 2022Article
- The role of environmental allergen control in the management of asthma.The World Allergy Organization journal · 2022Review
- Animal Allergens, Endotoxin, and β-(1,3)-Glucan in Small Animal Practices: Exposure Levels at Work and in Homes of Veterinary Staff.Annals of work exposures and health · 2022Article
- Article
- A Cross-Sectional Study of Knowledge on Ownership, Zoonoses and Practices among Pet Owners in Northern Portugal.Animals : an open access journal from MDPI · 2021Article
- Environmental endotoxin exposure and asthma.The Journal of allergy and clinical immunology · 2021Article
- The nasal microbiome, nasal transcriptome, and pet sensitization.The Journal of allergy and clinical immunology · 2021Article
- Current pet ownership modifies the adverse association between long-term ambient air pollution exposure and childhood asthma.Clinical and translational allergy · 2021Article
- Indoor endotoxin, proximity to a major roadway, and severe asthma exacerbations among children in Puerto Rico.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2020Article
- Indoor Microbial Exposures and Chronic Lung Disease: From Microbial Toxins to the Microbiome.Clinics in chest medicine · 2020Review
- Endotoxin clustering with allergens in house dust and asthma outcomes in a U.S. national study.Environmental health : a global access science source · 2020Article
- The effect of dog allergen exposure on asthma morbidity among inner-city children with asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020Observational
- Nasal Provocation Test with Cat and Dog Extracts: Results according to Molecular Components.Pulmonary medicine · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPets are major contributors of endotoxin in homes, but whether they influence endotoxin association with respiratory outcomes is unclear.
objectiveTo examine whether exposure and sensitization to dog and cat modify the relationship between endotoxin exposure and asthma and wheeze.
methodsWe analyzed data from 6051 participants in the 2005-2006 cycle of the National Health and Nutrition Examination Survey (NHANES). House dust from bedroom floor and bedding was evaluated for endotoxin and for dog (Canis familiaris 1) and cat (Feline domesticus 1) allergens. The NHANES also collected data on respiratory outcomes and measured IgE specific to allergens. Associations of log-endotoxin and pet exposure with respiratory outcomes were examined, adjusting for covariates including pet avoidance.
resultsDog and cat ownership among participants was 48.3% and 37.5%, respectively. Endotoxin geometric mean (SE) was 15.49 (0.50) EU/mg. Endotoxin and pet allergen levels were significantly higher in households with a dog or cat. Overall, endotoxin was positively associated with wheeze (odds ratio [OR], 1.30; 95% CI, 1.04-1.62), but not with asthma. However, in participants nonsensitized to dog, the odds of endotoxin association with wheeze were higher with exposure to dog allergen (OR, 1.80; 95% CI, 1.27-2.53; P
conclusionsExposure to dog and cat allergens enhances the association of endotoxin with asthma and wheeze.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.