ArticleGenome biology and evolution2018
The Most Developmentally Truncated Fishes Show Extensive Hox Gene Loss and Miniaturized Genomes.
Article in Genome biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Parallel shifts in differential gene expression reveal convergent miniaturization in fishes.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Evidence for Multiple Independent Expansions of Fox Gene Families Within Flatworms.Journal of molecular evolution · 2025Article
- The reference genome of Macropodus opercularis (the paradise fish).Scientific data · 2024Article
- Comparative genomics reveals insights into anuran genome size evolution.BMC genomics · 2023Article
- Draft Genome of White-blotched River Stingray Provides Novel Clues for Niche Adaptation and Skeleton Formation.Genomics, proteomics & bioinformatics · 2023Article
- Small Body, Large Chromosomes: Centric Fusions Shaped the Karyotype of the Amazonian Miniature FishGenes · 2023Article
- Transposable element and host silencing activity in gigantic genomes.Frontiers in cell and developmental biology · 2023Article
- Towards the phylogenetic placement of the enigmatic African genus Prolabeops Schultz, 1941.Journal of fish biology · 2022Article
- The comparative energetics of the ray-finned fish in an evolutionary context.Conservation physiology · 2022Article
- The emerging vertebrate model species for neurophysiological studies is Danionella cerebrum, new species (Teleostei: Cyprinidae).Scientific reports · 2021Article
- Of Traits and Trees: Probabilistic Distances under Continuous Trait Models for Dissecting the Interplay among Phylogeny, Model, and Data.Systematic biology · 2021Article
- A bird-like genome from a frog: Mechanisms of genome size reduction in the ornate burrowing frog,Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Insights into skull evolution in fossorial snakes, as revealed by the cranial morphology of Atractaspis irregularis (Serpentes: Colubroidea).Journal of anatomy · 2021Article
- Antigen receptor repertoires of one of the smallest known vertebrates.Science advances · 2021Article
- The genomic timeline of cichlid fish diversification across continents.Nature communications · 2020Article
- Genome of the four-finger threadfin Eleutheronema tetradactylum (Perciforms: Polynemidae).BMC genomics · 2020Article
- Insights into the Evolution of Neoteny from the Genome of the Asian Icefish Protosalanx chinensis.iScience · 2020Article
- Hybrid genome assembly and annotation of Danionella translucida.Scientific data · 2019Article
- Highlight: Big Surprises from the World's Smallest Fish.Genome biology and evolution · 2018Article
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10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The world's smallest fishes belong to the genus Paedocypris. These miniature fishes are endemic to an extreme habitat: the peat swamp forests in Southeast Asia, characterized by highly acidic blackwater. This threatened habitat is home to a large array of fishes, including a number of miniaturized but also developmentally truncated species. Especially the genus Paedocypris is characterized by profound, organism-wide developmental truncation, resulting in sexually mature individuals of <8 mm in length with a larval phenotype. Here, we report on evolutionary simplification in the genomes of two species of the dwarf minnow genus Paedocypris using whole-genome sequencing. The two species feature unprecedented Hox gene loss and genome reduction in association with their massive developmental truncation. We also show how other genes involved in the development of musculature, nervous system, and skeleton have been lost in Paedocypris, mirroring its highly progenetic phenotype. Further, our analyses suggest two mechanisms responsible for the genome streamlining in Paedocypris in relation to other Cypriniformes: severe intron shortening and reduced repeat content. As the first report on the genomic sequence of a vertebrate species with organism-wide developmental truncation, the results of our work enhance our understanding of genome evolution and how genotypes are translated to phenotypes. In addition, as a naturally simplified system closely related to zebrafish, Paedocypris provides novel insights into vertebrate development.
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