ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2018
The Impact of Dementia Diagnosis on Patterns of Potentially Inappropriate Medication Use Among Older Adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Medicine Optimisation and Deprescribing Intervention Outcomes for Older People with Dementia or Mild Cognitive Impairment: A Systematic Review.Drugs & aging · 2025Pooled it
- Implementing a conversation-starter tool to empower people with dementia and carers to have medicine conversations: a pilot and feasibility study.The Gerontologist · 2026Article
- Deprescribing Central Nervous System-Active Medications Among Community-Dwelling Older Adults with Dementia in Primary Care: A Feasibility Study.International journal of environmental research and public health · 2025Article
- Racial and ethnic disparities in potentially inappropriate medication use in patients with dementia.Journal of the American Geriatrics Society · 2024Article
- Preferences for deprescribing antihypertensive medications amongst clinicians, carers and people living with dementia: a discrete choice experiment.Age and ageing · 2023Article
- Potentially Inappropriate Medications Pre- and Post-Diagnosis of Major Neurocognitive Disorders Among Older People in Sweden: A Register-Based, 6-Year Longitudinal Study.Drugs & aging · 2022Article
- Treatment of bladder dysfunction with solifenacin: is there a risk of dementia or cognitive impairment?Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022Review
- Medications causing potential cognitive impairment are common in nursing home dementia units - A cross-sectional study.Exploratory research in clinical and social pharmacy · 2021Article
- Polypharmacy among older adults with dementia compared with those without dementia in the United States.Journal of the American Geriatrics Society · 2021Article
- An investigation of new medications initiation during ambulatory care visits in patients with dementia.Exploratory research in clinical and social pharmacy · 2021Article
- Frequency of and risk factors for potentially inappropriate medication use in Parkinson's disease.Age and ageing · 2020Article
- One-year persistence of potentially inappropriate medication use in older adults: A population-based study.British journal of clinical pharmacology · 2020Article
- Alzheimer's disease medication and outcomes of hospitalisation among patients with dementia.Epidemiology and psychiatric sciences · 2019Article
- Association Between Antipsychotics and All-Cause Mortality Among Community-Dwelling Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Anticholinergic medicines use among older adults before and after initiating dementia medicines.British journal of clinical pharmacology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Background: Use of potentially inappropriate medications (PIM) among people with dementia is common. We assessed the patterns of medication use from 1-year before dementia diagnosis, to 1-year after dementia diagnosis, compared with patterns of medication use in people without dementia. Methods: We conducted longitudinal study using the National Alzheimer's Coordinating Center data. Adults aged 65 years and older newly diagnosed with dementia (n = 2,418) during 2005-2015 were year, age, and sex matched 1:1 with controls. Generalized estimating equation models weighted for missingness and adjusted for 15 participant characteristics were fit. Results: Among participants with dementia, number of medications reported 1-year prediagnosis was 8% lower than at diagnosis year (p < .0001) and 11% higher 1-year postdiagnosis compared with year of diagnosis (p < .0001). Among participants with dementia, the odds of PIM exposure, assessed using the 2015 Beers Criteria, was 17% lower 1-year prediagnosis (p < .0001) and 17% higher 1-year postdiagnosis (p = .006) compared with year of diagnosis. Among controls, there were approximately 6% more medications reported between consecutive years (p < .0001 each comparison) and the odds of PIM exposure increased 11% between consecutive years (p = .006 and p = .047). At each annual follow-up, participants with dementia had lower odds of PIM exposure than their controls (prediagnosis p < .0001, at diagnosis p = .0007, postdiagnosis p = .03, respectively). There were no differences in exposure to anticholinergic medications. Conclusions: Number of medications and PIM use increased annually for participants with and without dementia. Persistent challenge of increasing PIM use in this group of older adults is of major concern and warrants interventions to minimize such prescribing.
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