ArticlePLoS genetics2018
WUSCHEL-RELATED HOMEOBOX4 acts as a key regulator in early leaf development in rice.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 64 citations in OpenAlex.
- Phylogenomic analysis supports the deep and gradual evolution of water-conducting tissues.Plant physiology · 2026Article
- Pangenome and Pan-Transcriptome Analysis of theEcology and evolution · 2026Article
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- WUSCHEL Transcription Factor: From Stem Cell Maintenance to Crop Improvement.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Evolutionary adaptations to the hormonal regulation of vascular tissue development.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genome-wide identification of WOX transcription factors and functional characterization of WOX4 and WOX13 involved in cold stress responseFrontiers in genetics · 2026Article
- The C2H2 Zinc-Finger protein ELR1 negatively regulates cytokinin metabolism and signaling pathway in rice.Functional & integrative genomics · 2025Article
- SHORT AND CROOKED AWN, encoding the epigenetic regulator EMF1, promotes barley awn development.Plant & cell physiology · 2025Article
- Plant developmental oddities.Planta · 2024Review
- Spatially distributed cytokinins: Metabolism, signaling, and transport.Plant communications · 2024Review
- Advancements in Rice Leaf Development Research.Plants (Basel, Switzerland) · 2024Review
- WOX2 functions redundantly with WOX1 and WOX4 to positively regulate seed germination in Arabidopsis.Planta · 2024Article
- Identification of a potential homeodomain-like gene governing leaf size and venation architecture in birch.Frontiers in plant science · 2024Article
- A Comprehensive Identification and Expression Analysis of the WUSCHEL Homeobox-Containing Protein Family Reveals Their Special Role in Development and Abiotic Stress Response inInternational journal of molecular sciences · 2023Article
- Genetic basis controlling rice plant architecture and its modification for breeding.Breeding science · 2023Article
- Identification of a Rice Leaf Width GeneInternational journal of molecular sciences · 2023Article
- Multi-model genome-wide association studies of leaf anatomical traits and vein architecture in rice.Frontiers in plant science · 2023Article
- A splice site mutation in theHorticulture research · 2023Article
- The APC/CTAD1-WIDE LEAF 1-NARROW LEAF 1 pathway controls leaf width in rice.The Plant cell · 2022Article
- Vascular function of the T3/modern clade WUSCHEL-Related HOMEOBOX transcription factor genes predate apical meristem-maintenance function.BMC plant biology · 2022Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rice (Oryza sativa) has long and narrow leaves with parallel veins, similar to other grasses. Relative to Arabidopsis thaliana which has oval-shaped leaves, our understanding of the mechanism of leaf development is insufficient in grasses. In this study, we show that OsWOX4, a member of the WUSCHEL-RELATED HOMEOBOX gene family, plays important roles in early leaf development in rice. Inducible downregulation of OsWOX4 resulted in severe defects in leaf development, such as an arrest of vascular differentiation, a partial defect in the early cell proliferation required for midrib formation, and a failure to maintain cellular activity in general parenchyma cells. In situ analysis showed that knockdown of OsWOX4 reduced the expression of two LONELY GUY genes, which function in the synthesis of active cytokinin, in developing vascular bundles. Consistent with this, cytokinin levels were downregulated by OsWOX4 knockdown. Transcriptome analysis further showed that OsWOX4 regulates multiple genes, including those responsible for cell cycle progression and hormone action, consistent with the effects of OsWOX4 downregulation on leaf phenotypes. Collectively, these results suggest that OsWOX4 acts as a key regulator at an early stage of leaf development. Our previous work revealed that OsWOX4 is involved in the maintenance of shoot apical meristem in rice, whereas AtWOX4 is specifically associated with the maintenance of vascular stem cells in Arabidopsis. Thus, the function of the two orthologous genes seems to be diversified between rice and Arabidopsis.
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