ArticlePLoS biology2018
In vivo clonal analysis reveals spatiotemporal regulation of thalamic nucleogenesis.
Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Early lineage divergence segregates sensory and motor-associative identities in the thalamus.Nature neuroscience · 2026Article
- Sensory modality-specific wiring of thalamocortical circuits.Nature reviews. Neuroscience · 2025Review
- Ethanol exposure promotes tumor cell migration and angiogenesis in a mouse model of glioblastoma.Alcohol (Fayetteville, N.Y.) · 2025Article
- Probing Cell-Type Specificity of Mutant Phenotype at Transcriptomic Level Using Mosaic Analysis with Double Markers (MADM).Methods in molecular biology (Clifton, N.J.) · 2025Article
- Perinatal development of structural thalamocortical connectivity.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Transcription factors ASCL1 and OLIG2 drive glioblastoma initiation and co-regulate tumor cell types and migration.Nature communications · 2024Article
- Epigenetic maintenance of adult neural stem cell quiescence in the mouse hippocampus via Setd1a.Nature communications · 2024Article
- Spatiotemporal molecular dynamics of the developing human thalamus.Science (New York, N.Y.) · 2023Article
- A phylogenetically-conserved axis of thalamocortical connectivity in the human brain.Nature communications · 2023Article
- β-Catenin and SOX2 Interaction Regulate Visual Experience-Dependent Cell Homeostasis in the DevelopingInternational journal of molecular sciences · 2023Article
- Developmental trajectories of thalamic progenitors revealed by single-cell transcriptome profiling and Shh perturbation.Cell reports · 2022Article
- Hypothalamic RaxNature communications · 2021Article
- Article
- Astrocytes and neurons share region-specific transcriptional signatures that confer regional identity to neuronal reprogramming.Science advances · 2021Article
- Article
- TCF7L2 regulates postmitotic differentiation programmes and excitability patterns in the thalamus.Development (Cambridge, England) · 2020Article
- A repeated molecular architecture across thalamic pathways.Nature neuroscience · 2019Article
- Emerging connections between cerebellar development, behaviour and complex brain disorders.Nature reviews. Neuroscience · 2019Review
- Article
- Relationships between neuronal birthdates and tonotopic positions in the mouse cochlear nucleus.The Journal of comparative neurology · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The thalamus, a crucial regulator of cortical functions, is composed of many nuclei arranged in a spatially complex pattern. Thalamic neurogenesis occurs over a short period during mammalian embryonic development. These features have hampered the effort to understand how regionalization, cell divisions, and fate specification are coordinated and produce a wide array of nuclei that exhibit distinct patterns of gene expression and functions. Here, we performed in vivo clonal analysis to track the divisions of individual progenitor cells and spatial allocation of their progeny in the developing mouse thalamus. Quantitative analysis of clone compositions revealed evidence for sequential generation of distinct sets of thalamic nuclei based on the location of the founder progenitor cells. Furthermore, we identified intermediate progenitor cells that produced neurons populating more than one thalamic nuclei, indicating a prolonged specification of nuclear fate. Our study reveals an organizational principle that governs the spatial and temporal progression of cell divisions and fate specification and provides a framework for studying cellular heterogeneity and connectivity in the mammalian thalamus.
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