ReviewAnesthesiology2018
Role of Network Science in the Study of Anesthetic State Transitions.
Review in Anesthesiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- EEG-guided sevoflurane anesthesia vs. standard care in pediatric emergence delirium: a grade-assessed systematic review and meta-analysis with trial sequential analysis.Journal of anesthesia · 2026Pooled it
- Detection of Electrophysiological Activity of Amygdala during Anesthesia Using Stereo-EEG: A Preliminary Research in Anesthetized Epileptic Patients.BioMed research international · 2020Trial
- Opposite network patterns of integration-segregation in psychedelic and sedated states of consciousness.Cell reports · 2026Article
- Comparative Mapping of Functional and Structural Homologies in the Pig and Human Brain.bioRxiv : the preprint server for biology · 2026Article
- Characteristics of electroencephalographic changes induced by different hypnotics in elderly patients: a narrative review.Korean journal of anesthesiology · 2026Review
- Opposing Network Patterns of Integration-Segregation in Psychedelic and Sedated States of Consciousness.bioRxiv : the preprint server for biology · 2026Article
- Neurophysiological connectomic signatures of consciousness during propofol-induced general anesthesia.Cell reports. Medicine · 2026Article
- Protocol for modulating anesthesia delta oscillations using closed loop auditory stimulation.Frontiers in human neuroscience · 2026Article
- Distinct effects of global signal regression on brain activity during propofol and sevoflurane anesthesia.Frontiers in neuroscience · 2025Article
- Combined effects of landscape fragmentation and sampling frequency of movement data on the assessment of landscape connectivity.Movement ecology · 2024Article
- Common functional mechanisms underlying dynamic brain network changes across five general anesthetics: A rat fMRI study.CNS neuroscience & therapeutics · 2024Article
- Intraoperative pediatric electroencephalography monitoring: an updated review.Korean journal of anesthesiology · 2024Review
- Anesthesia and the neurobiology of consciousness.Neuron · 2024Review
- Metabolic Connectome and Its Role in the Prediction, Diagnosis, and Treatment of Complex Diseases.Metabolites · 2024Review
- The nature of consciousness in anaesthesia.BJA open · 2023Review
- Dose-related adaptive reconstruction of DMN in isoflurane administration: a study in the rat.BMC anesthesiology · 2023Article
- The effects of propofol anaesthesia on molecular-enriched networks during resting-state and naturalistic listening.NeuroImage · 2023Article
- Highly connected and highly variable: A Core brain network during resting state supports Propofol-induced unconsciousness.Human brain mapping · 2023Article
- A scoping review for building a criticality-based conceptual framework of altered states of consciousness.Frontiers in systems neuroscience · 2023Article
- EEG functional connectivity is sensitive for nitrogen narcosis at 608 kPa.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The heterogeneity of molecular mechanisms, target neural circuits, and neurophysiologic effects of general anesthetics makes it difficult to develop a reliable and drug-invariant index of general anesthesia. No single brain region or mechanism has been identified as the neural correlate of consciousness, suggesting that consciousness might emerge through complex interactions of spatially and temporally distributed brain functions. The goal of this review article is to introduce the basic concepts of networks and explain why the application of network science to general anesthesia could be a pathway to discover a fundamental mechanism of anesthetic-induced unconsciousness. This article reviews data suggesting that reduced network efficiency, constrained network repertoires, and changes in cortical dynamics create inhospitable conditions for information processing and transfer, which lead to unconsciousness. This review proposes that network science is not just a useful tool but a necessary theoretical framework and method to uncover common principles of anesthetic-induced unconsciousness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.