ArticleJournal of comparative psychology (Washington, D.C. : 1983)2018
Application of a novel social choice paradigm to assess effects of prenatal endocrine-disrupting chemical exposure in rats (Rattus norvegicus).
Article in Journal of comparative psychology (Washington, D.C. : 1983), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Prenatal Exposure to an EDC Mixture, NeuroMix: Effects on Brain, Behavior, and Stress Responsiveness in Rats.Toxics · 2022Article
- Article
- Two Hits of EDCs Three Generations Apart: Effects on Social Behaviors in Rats, and Analysis by Machine Learning.Toxics · 2022Article
- Effects of endocrine-disrupting chemicals on hypothalamic oxytocin and vasopressin systems.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2022Article
- Transgenerational effects of polychlorinated biphenyls: 2. Hypothalamic gene expression in rats†.Biology of reproduction · 2021Article
- Review
- Evidence Implicating Non-Dioxin-Like Congeners as the Key Mediators of Polychlorinated Biphenyl (PCB) Developmental Neurotoxicity.International journal of molecular sciences · 2020Review
- Endocrine-disrupting chemicals: Effects on neuroendocrine systems and the neurobiology of social behavior.Hormones and behavior · 2019Review
- Social and neuromolecular phenotypes are programmed by prenatal exposures to endocrine-disrupting chemicals.Molecular and cellular endocrinology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Endocrine-disrupting chemical (EDC) exposures during critical periods of gestation cause long-lasting behavioral effects, presumably by disturbing hormonal organization of the brain. Among such EDCs are polychlorinated biphenyls (PCBs), a class of industrial chemicals. PCB exposure in utero leads to alterations in mating behaviors and other sexually dimorphic social interactions in rats. Many of the previous studies on social behavior gave the experimental animal a single or binary choice. This study applied a more complex behavioral apparatus, an X-shaped Plexiglas apparatus (FourPlex), that enabled an experimental animal exposed to PCBs or a vehicle to distinguish and choose among 4 stimulus animals of the same or opposite sex, and of different hormonal status. We found that rats were able to differentiate among the stimuli in the FourPlex and showed the expected preference for an opposite sex, hormone-treated rat, particularly for behaviors conducted in proximity. Prenatal treatment caused subtle shifts in behavior toward stimulus rats in the FourPlex; more robust effects were seen for the sexual dimorphisms in behavior. Importantly, the results differ from our previous results of a simple binary choice model, showing that how an animal behaves in a more complex social paradigm does not predict the outcome in a simple choice model, and vice versa. (PsycINFO Database Record
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Registered trials
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