Evidence map›Paper›PMID 29683498›Full record

Trial reportJournal of periodontology2018

Advanced platelet-rich fibrin and freeze-dried bone allograft for ridge preservation: A randomized controlled clinical trial.

Daniel Clark, Yogalakshmi Rajendran, Sarmad Paydar, Sunita Ho, Darren Cox, Mark Ryder, John Dollard, Richard T Kao

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of periodontology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 83 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03851289 nacompletednot on this map

Combination of Platelet-Rich Fibrin and Calcium Sulfate in Socket Augmentation

TypeinterventionalSponsorUniversity of MalayaRan2016 to 2018Enrolled10ConditionsTooth ExtractionArmsplatelet-rich fibrin and calcium sulfate, platelet-rich fibrin and xenograft
NCT05031169 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Evaluation of Surgical Management of Interdental Papilla Recession With Advanced Platelet Rich Fibrin Compared to Subepthelial Connective Tissue Graft. A Randomized Controlled Trial

TypeinterventionalSponsorCairo UniversityRan2020 to 2022Enrolled32ConditionsRecessionArmsinterdental papilla surgical reconstructiion
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 14 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniel ClarkDepartment of Orofacial Sciences, Division of Periodontology, University of California San Francisco, San Francisco, CA.
Yogalakshmi RajendranDepartment of Orofacial Sciences, Division of Periodontology, University of California San Francisco, San Francisco, CA.
Sarmad PaydarDepartment of Orofacial Sciences, Division of Periodontology, University of California San Francisco, San Francisco, CA.
Sunita HoDepartment of Preventive and Restorative Dental Sciences , Division of Biomaterials and Bioengineering University of California San Francisco, San Francisco, CA.
Darren CoxArthur A. Dugoni School of Dentistry, University of the Pacific, San Francisco, CA.
Mark RyderDepartment of Orofacial Sciences, Division of Periodontology, University of California San Francisco, San Francisco, CA.
John DollardDepartment of Orofacial Sciences, Division of Periodontology, University of California San Francisco, San Francisco, CA.
Richard T KaoDepartment of Orofacial Sciences, Division of Periodontology, University of California San Francisco, San Francisco, CA.

Funding

UCSF INTEGRATED DDS-PHD TRAINING PROGRAMT32DE007306 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Yukiko Nakano · 1996 to 2026
$15.4M
NIDCR NIH HHS T32 DE007306
6 · The paper itself

Abstract

backgroundAdvanced platelet-rich fibrin (A-PRF) is an autogenous blood product with applications in dento-alveolar surgery. However, there is minimal information regarding its optimal clinical application or efficacy. The aim of this multi-arm parallel randomized controlled clinical trial was to evaluate the efficacy of A-PRF alone or with freeze-dried bone allograft (FDBA) in improving vital bone formation and alveolar dimensional stability during ridge preservation.

methodsForty patients requiring extraction of non-molar teeth and replacement with dental implants were randomized into one of four ridge preservation approaches: A-PRF, A-PRF+FDBA, FDBA, or blood clot. A-PRF was prepared at 1,300 rpm for 8 minutes. Non-traumatic extractions and ridge preservation was performed. After an average of 15 weeks healing, bone core samples were harvested at the time of implant placement for micro-CT and histomorphometric analysis. Ridge dimensions were measured immediately after extraction and before implant placement.

resultsSignificantly greater loss of ridge height was noted in the blood clot group (3.8 ± 2.0 mm) compared to A-PRF (1.8 ± 2.1 mm) and A-PRF+FDBA (1.0 ± 2.3 mm) groups (P < 0.05). No significant differences in ridge width reduction were noted between groups. Significantly more vital bone was present in the A-PRF group (46% ± 18%) compared to the FDBA group (29% ± 14%) (P < 0.05). Bone mineral density was significantly greater in the FDBA group (551 ± 58 mg/cm

conclusionsThis study demonstrates A-PRF alone or augmented with FDBA is a suitable biomaterial for ridge preservation. This study represents the first randomized controlled clinical trial comparing A-PRF with and without FDBA to FDBA alone for ridge preservation.

Indexed as

Alveolar Ridge AugmentationPlatelet-Rich FibrinAllograftsAlveolar ProcessBone TransplantationHumansTooth ExtractionTooth Socketbiomaterialsbone regenerationclinical trialridge preservation

Identifiers

PMID29683498
PMCPMC6483085

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.