ArticleChemical communications (Cambridge, England)2018
Long-wavelength TCF-based fluorescence probes for the detection and intracellular imaging of biological thiols.
Article in Chemical communications (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A Red-Emission Fluorescent Probe with Large Stokes Shift for Detection of Viscosity in Living Cells and Tumor-Bearing Mice.Molecules (Basel, Switzerland) · 2024Article
- Fluorescent Sensing of Glutathione and Related Bio-Applications.Biosensors · 2022Review
- Fluorescein Based Fluorescence Sensors for the Selective Sensing of Various Analytes.Journal of fluorescence · 2021Review
- A Phenothiazine-HPQ Based Fluorescent Probe with a Large Stokes Shift for Sensing Biothiols in Living Systems.Molecules (Basel, Switzerland) · 2021Article
- Nile-Red-Based Fluorescence Probe for Selective Detection of Biothiols, Computational Study, and Application in Cell Imaging.Molecules (Basel, Switzerland) · 2020Article
- Article
- A fluorescent ESIPT-based benzimidazole platform for the ratiometric two-photon imaging of ONOOChemical science · 2020Article
- Coumarin-based fluorescent probe for the rapid detection of peroxynitrite 'AND' biological thiols.RSC advances · 2020Article
- A Copper (II) Ensemble-Based Fluorescence Chemosensor and Its Application in the 'Naked-Eye' Detection of Biothiols in Human Urine.Sensors (Basel, Switzerland) · 2020Article
- Protein Encapsulation: A Nanocarrier Approach to the Fluorescence Imaging of an Enzyme-Based Biomarker.Frontiers in chemistry · 2020Article
- Reaction-Based Fluorescent Probes for the Detection and Imaging of Reactive Oxygen, Nitrogen, and Sulfur Species.Accounts of chemical research · 2019Review
- Long Wavelength TCF-Based Fluorescent Probe for the Detection of Alkaline Phosphatase in Live Cells.Frontiers in chemistry · 2019Article
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Authors and funding
9 authors.
Funding
Abstract
Two 'turn on' TCF-based fluorescence probes were developed for the detection of biological thiols (TCF-GSH and TCFCl-GSH). TCF-GSH was shown to have a high sensitivity towards glutathione (GSH) with a 0.28 μM limit of detection. Unfortunately, at higher GSH concentrations the fluorescence intensity of TCF-GSH decreased and toxicity was observed for TCF-GSH in live cells. However, TCFCl-GSH was shown to be able to detect GSH at biologically relevant concentrations with a 0.45 μM limit of detection. No toxicity was found for TCFCl-GSH and a clear 'turn on' with good photostability was observed for the exogenous addition of GSH, Cys and HCys. Furthermore, TCFCl-GSH was used to evaluate the effects of drug treatment on the levels of GSH in live cells.
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