Evidence map›Paper›PMID 29683273›Full record

ArticleAdvanced healthcare materials2018

Micelle-Coated, Hierarchically Structured Nanofibers with Dual-Release Capability for Accelerated Wound Healing and Infection Control.

Victoria Albright, Meng Xu, Anbazhagan Palanisamy, Jun Cheng, Mary Stack, Beilu Zhang, Arul Jayaraman, Svetlana A Sukhishvili, Hongjun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Three-Dimensional Scaffolds for Bone Tissue Engineering.Bioengineering (Basel, Switzerland) · 2023
    Review
  6. Article
  7. Review
  8. Electrospinning of botanicals for skin wound healing.Frontiers in bioengineering and biotechnology · 2022
    Review
  9. Article
  10. Protein-Based Systems for Topical Antibacterial Therapy.Frontiers in medical technology · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Victoria AlbrightDepartment of Materials Science and Engineering, Texas A&M University, 575 Ross Street, College Station, TX, 77843, USA.
Meng XuDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, 1 Castle Point on the Hudson, Hoboken, NJ, 07030, USA.
Anbazhagan PalanisamyDepartment of Materials Science and Engineering, Texas A&M University, 575 Ross Street, College Station, TX, 77843, USA.ORCID 0000-0002-8366-3330
Jun ChengDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, 1 Castle Point on the Hudson, Hoboken, NJ, 07030, USA.
Mary StackDepartment of Biomedical Engineering, Stevens Institute of Technology, 1 Castle Point on the Hudson, Hoboken, NJ, 07030, USA.
Beilu ZhangDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, 1 Castle Point on the Hudson, Hoboken, NJ, 07030, USA.
Arul JayaramanDepartment of Chemical Engineering, Department of Biomedical Engineering, Texas A&M University, 0386 Spence Street, College Station, TX, 77843, USA.ORCID 0000-0001-9276-8284
Svetlana A SukhishviliDepartment of Materials Science and Engineering, Texas A&M University, 575 Ross Street, College Station, TX, 77843, USA.ORCID 0000-0002-2328-4494
Hongjun WangDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, 1 Castle Point on the Hudson, Hoboken, NJ, 07030, USA.

Funding

Micro- and nanofiber enabled biomimetic periosteum for bone repair and reconstructionR01AR067859 · NIAMS · UNIVERSITY OF ROCHESTER · PI WANG, HONGJUN, ZHANG, XINPING · 2016 to 2020
$2.7M
NIAMS NIH HHS R01 AR067859
6 · The paper itself

Abstract

Tailoring nanofibrous matrices-a material with much promise for wound healing applications-to simultaneously mitigate bacterial colonization and stimulate wound closure of infected wounds is highly desirable. To that end, a dual-releasing, multiscale system of biodegradable electrospun nanofibers coated with biocompatible micellar nanocarriers is reported. For wound healing, transforming growth factor-β1 is incorporated into polycaprolactone/collagen (PCL/Coll) nanofibers via electrospinning and the myofibroblastic differentiation of human dermal fibroblasts is locally stimulated. To prevent infection, biocompatible nanocarriers of polypeptide-based block copolymer micelles are deposited onto the surfaces of PCL/Coll nanofibers using tannic acid as a binding partner. Micelle-modified fibrous scaffolds are favorable for wound healing, not only supporting the attachment and spreading of fibroblasts comparable to those on noncoated nanofibers, but also significantly enhancing fibroblast migration. Micellar coatings can be loaded with gentamicin or clindamycin and exhibit antibacterial activity as measured by Petrifilm and zone of inhibition assays as well as time-dependent reduction of cellular counts of Staphylococcus aureus cultures. Moreover, delivery time of antibiotic dosage is tunable through the application of a novel modular approach. Altogether, this system holds great promise as an infection-mitigating, cell-stimulating, biodegradable skin graft for wound management and tissue engineering.

Indexed as

Coated Materials, BiocompatibleMicellesNanofibersCell LineCell MovementClindamycinDermisFibroblastsGentamicinsHumansStaphylococcal InfectionsStaphylococcus aureusTransforming Growth Factor beta1Wound HealingClindamycinCoated Materials, BiocompatibleGentamicinsMicellesTGFB1 protein, humanTransforming Growth Factor beta1dual drug releaseinfection preventionlayer-by-layernanofibrous matriceswound healing

Identifiers

PMID29683273
PMCPMC6347427

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.