Evidence map›Paper›PMID 29682821›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2018

Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe.

Weizhi Wang, Zhuoran Ma, Shoujun Zhu, Hao Wan, Jingying Yue, Huilong Ma, Rui Ma, Qinglai Yang, Zihua Wang, Qian Li and 11 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 149 citations in OpenAlex.

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  8. Tissue-seeking dyes for in vivo applications.Smart molecules : open access · 2024
    Review
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  11. Charge barriers in the kidney elimination of engineered nanoparticles.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Anti-Cancer Peptides: Status and Future Prospects.Molecules (Basel, Switzerland) · 2023
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 2 countries.

Weizhi WangCAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, China.
Zhuoran MaDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Shoujun ZhuDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Hao WanDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Jingying YueDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Huilong MaDepartment of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen, 518055, China.
Rui MaDepartment of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen, 518055, China.
Qinglai YangDepartment of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen, 518055, China.
Zihua WangCAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, China.
Qian LiInstitute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Yixia QianCAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, China.
Chunyan YueCAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, China.
Yuehua WangCAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, China.
Linyang FanCAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, China.
Yeteng ZhongDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Ying ZhouDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Hongpeng GaoDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Junshan RuanDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Zhiyuan HuCAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, China.
Yongye LiangDepartment of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen, 518055, China.
Hongjie DaiDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Stanford University · USNational Center for Nanoscience and Technology · CNSouthern University of Science and Technology · CNChinese Academy of Sciences · CNInstitute of Chemistry · CNShenzhen Technology University · CN

Funding

Human Infrared Vision at Molecular and Cellular ScaleDP1NS105737 · NINDS · STANFORD UNIVERSITY · PI DAI, HONGJIE · 2017 to 2022
$5.5M
NINDS NIH HHS DP1 NS105737
6 · The paper itself

Abstract

In vivo molecular imaging of tumors targeting a specific cancer cell marker is a promising strategy for cancer diagnosis and imaging guided surgery and therapy. While targeted imaging often relies on antibody-modified probes, peptides can afford targeting probes with small sizes, high penetrating ability, and rapid excretion. Recently, in vivo fluorescence imaging in the second near-infrared window (NIR-II, 1000-1700 nm) shows promise in reaching sub-centimeter depth with microscale resolution. Here, a novel peptide (named CP) conjugated NIR-II fluorescent probe is reported for molecular tumor imaging targeting a tumor stem cell biomarker CD133. The click chemistry derived peptide-dye (CP-IRT dye) probe afforded efficient in vivo tumor targeting in mice with a high tumor-to-normal tissue signal ratio (T/NT > 8). Importantly, the CP-IRT probes are rapidly renal excreted (≈87% excretion within 6 h), in stark contrast to accumulation in the liver for typical antibody-dye probes. Further, with NIR-II emitting CP-IRT probes, urethra of mice can be imaged fluorescently for the first time noninvasively through intact tissue. The NIR-II fluorescent, CD133 targeting imaging probes are potentially useful for human use in the clinic for cancer diagnosis and therapy.

Indexed as

AnimalsCell Line, TumorClick ChemistryFluorescent DyesMiceMolecular ImagingPeptidesSpectroscopy, Near-InfraredFluorescent DyesPeptidesmolecular imagingpeptide proberenal-excretionsecond near-infrared windowtumor targeting

Identifiers

PMID29682821
PMCPMC6485425
OpenAlexW2801222834

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.