Evidence map›Paper›PMID 29682793›Full record

ArticleDiabetic medicine : a journal of the British Diabetic Association2018

Salbutamol-induced electrophysiological changes show no correlation with electrophysiological changes during hyperinsulinaemic-hypoglycaemic clamp in young people with Type 1 diabetes.

P Novodvorsky, A Bernjak, E J Robinson, A Iqbal, I A Macdonald, R M Jacques, J L B Marques, P J Sheridan, S R Heller

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetic medicine : a journal of the British Diabetic Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

P NovodvorskyDepartment of Oncology and Metabolism, University of Sheffield.
A BernjakDepartment of Oncology and Metabolism, University of Sheffield.
E J RobinsonDepartment of Oncology and Metabolism, University of Sheffield.
A IqbalDepartment of Oncology and Metabolism, University of Sheffield.
I A MacdonaldSchool of Life Sciences, University of Nottingham, Nottingham.
R M JacquesSchool of Health and Related Research, University of Sheffield, Sheffield, UK.ORCID http://orcid.org/0000-0001-6710-5403
J L B MarquesDepartment of Oncology and Metabolism, University of Sheffield.
P J SheridanSheffield Teaching Hospitals NHS Foundation Trust.
S R HellerDepartment of Oncology and Metabolism, University of Sheffield.ORCID http://orcid.org/0000-0002-2425-9565
Sheffield Teaching Hospitals NHS Foundation Trust · GBUniversity of Sheffield · GBInsigneo · GBUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsHypoglycaemia causes QT-interval prolongation and appears pro-arrhythmogenic. Salbutamol, a β

methodsEighteen individuals with Type 1 diabetes were administered 2.5 mg of nebulized salbutamol. Participants then underwent a hyperinsulinaemic-hypoglycaemic clamp (2.5 mmol/l for 1 h). During both experiments, heart rate and serum potassium (and catecholamines during the clamp) were measured and a high-resolution electrocardiogram (ECG) was recorded at pre-set time points. Cardiac repolarization was measured by QT-interval duration adjusted for heart rate (QT

resultsSalbutamol administration caused QT

conclusionsBoth hypoglycaemia and salbutamol caused pro-arrhythmogenic electrophysiological changes in people with Type 1 diabetes but were not related in any given individual. Salbutamol does not appear useful in assessing an individual's electrophysiological response to hypoglycaemia.

Identifiers

PMID29682793
PMCPMC6099209
OpenAlexW2800517079

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.