Evidence map›Paper›PMID 29682700›Full record

ArticleMolecular neurobiology2019

Therapeutic Potential of a Combination of Electroacupuncture and TrkB-Expressing Mesenchymal Stem Cells for Ischemic Stroke.

Sung Min Ahn, Yu Ri Kim, Yong-Il Shin, Ki Tae Ha, Seo-Yeon Lee, Hwa Kyoung Shin, Byung Tae Choi

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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  13. Treatment of ischemic stroke with modified mesenchymal stem cells.International journal of medical sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sung Min AhnKorean Medical Science Research Center for Healthy-Aging, Pusan National University, Yangsan, 50612, Republic of Korea.
Yu Ri KimKorean Medical Science Research Center for Healthy-Aging, Pusan National University, Yangsan, 50612, Republic of Korea.
Yong-Il ShinDepartment of Rehabilitation Medicine, School of Medicine, Pusan National University, Yangsan, 50612, Republic of Korea.
Ki Tae HaKorean Medical Science Research Center for Healthy-Aging, Pusan National University, Yangsan, 50612, Republic of Korea.
Seo-Yeon LeeKorean Medical Science Research Center for Healthy-Aging, Pusan National University, Yangsan, 50612, Republic of Korea.
Hwa Kyoung ShinKorean Medical Science Research Center for Healthy-Aging, Pusan National University, Yangsan, 50612, Republic of Korea.
Byung Tae ChoiKorean Medical Science Research Center for Healthy-Aging, Pusan National University, Yangsan, 50612, Republic of Korea. choibt@pusan.ac.kr.ORCID http://orcid.org/0000-0002-5965-4346
Pusan National University · KR

Funding

National Research Foundation of Korea 2014R1A5A2009936National Research Foundation of Korea 2015R1A2A2A03006712
6 · The paper itself

Abstract

We prepared and grafted tropomyosin receptor kinase B (TrkB) gene-transfected mesenchymal stem cells (TrkB-MSCs) into the ischemic penumbra and investigated whether electroacupuncture (EA) treatment could promote functional recovery from ischemic stroke. For the behavioral test, TrkB-MSCs+EA resulted in significantly improved motor function compared to that obtained with MSCs+EA or TrkB-MSCs alone. At 30 days after middle cerebral artery occlusion (MCAO), the largest number of grafted MSCs was detected in the TrkB-MSC+EA group. Some differentiation into immature neuroblasts and astrocytes was detected; however, only a few mature neuron-like cells were found. Compared to other treatments, TrkB-MSCs+EA upregulated the expression of mature brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT4) and induced the activation of TrkB receptor and its transcription factor cAMP response element-binding protein (CREB). At 60 days after MCAO, EA highly promoted the differentiation of TrkB-MSCs into mature neuron-like cells compared to the effect in MSCs. A selective TrkB antagonist, ANA-12, reverted the effect of TrkB-MSCs+EA in motor function recovery and survival of grafted MSCs. Our results suggest that EA combined with grafted TrkB-MSCs promotes the expression of BDNF and NT4, induces the differentiation of TrkB-MSCs, and improves motor function. TrkB-MSCs could serve as effective therapeutic agents for ischemic stroke if used in combination with BDNF/NT4-inducing therapeutic approaches.

Indexed as

ElectroacupunctureMesenchymal Stem Cell TransplantationAnimalsAstrocytesAzepinesBenzamidesBrain-Derived Neurotrophic FactorBrain IschemiaCell DifferentiationCell SurvivalCombined Modality TherapyGene Expression RegulationMaleMesenchymal Stem CellsMice, Inbred C57BLMotor ActivityANA 12 compoundAzepinesBenzamidesBrain-Derived Neurotrophic FactorNerve Growth Factorsneurotrophin 4Receptor, trkBBrain-derived neurotrophic factorElectroacupunctureIschemic strokeMesenchymal stem cellsNeurotrophin-4Tropomyosin receptor kinase B

Identifiers

PMID29682700
OpenAlexW2800934047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.