Evidence map›Paper›PMID 29682688›Full record

ReviewClinical oral investigations2018

What is the benefit of using amniotic membrane in oral surgery? A comprehensive review of clinical studies.

M Fénelon, S Catros, J C Fricain

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Biomaterials strategy for promoting palatal wound healing.Frontiers in bioengineering and biotechnology · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Perinatal derivatives: How to best characterize their multimodal functionsFrontiers in bioengineering and biotechnology · 2022
    Review
  11. Article
  12. Human amniotic membrane application in oral surgery-AnFrontiers in bioengineering and biotechnology · 2022
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. A Review on Modifications of Amniotic Membrane for Biomedical Applications.Frontiers in bioengineering and biotechnology · 2020
    Review
  19. Amniotic Membrane In Palatal Epithelial-Connective Tissue Reconstruction.International medical case reports journal · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

M FénelonCHU Bordeaux, Dentistry and Oral Health Department, Place Amélie Raba Léon, 33076, Bordeaux, France. mathilde.fenelon@u-bordeaux.fr.
S CatrosCHU Bordeaux, Dentistry and Oral Health Department, Place Amélie Raba Léon, 33076, Bordeaux, France.
J C FricainCHU Bordeaux, Dentistry and Oral Health Department, Place Amélie Raba Léon, 33076, Bordeaux, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSince its first use for the reconstruction of tissue defects in the oral cavity in 1985, human amniotic membrane (hAM) has been widely studied in the field of oral surgery. Despite the growing number of publications in this field, there is no systematic review or meta-analysis concerning its clinical applications, outcome assessments, and relevance in oral surgery. The aim of this review is to provide a thorough understanding of the potential use of hAM for soft and hard tissue reconstruction in the oral cavity. MATERIALS AND

methodsA systematic electronic and a manual literature search of the MEDLINE-PubMed database and Scopus database was completed. Patient, Intervention, Comparison and Outcomes (PICO) technique was used to select the relevant articles to meet the objective. Studies using hAM for oral reconstruction, and conducted on human subjects, were included in this survey.

resultsA total of 17 articles were analyzed. Five areas of interest were identified as potential clinical application: periodontal surgery, cleft palate and tumor reconstruction, prosthodontics and peri-implant surgery. Overall, periodontal surgery was the only discipline to assess the efficacy of hAM with randomized clinical trials. The wide variability of preservation methods of hAM and the lack of objective measurements were observed in this study.

conclusionhAM is already used in the field of oral surgery. Despite this, there is weak clinical evidence demonstrating convincingly the benefit of hAM in this area compared to standard surgery. CLINICAL RELEVANCE: Several studies now suggest the interest of hAM for periodontal tissue repair. Due to its biological and mechanical properties, hAM seems to be a promising treatment for wound healing in various areas of oral reconstruction. However, further randomized clinical trials are needed to confirm these preliminary results.

Indexed as

Oral Surgical ProceduresAmnionBiological DressingsEvidence-Based MedicineHumansAmniotic membraneGuided bone regenerationGuided tissue regenerationOral surgery

Identifiers

PMID29682688

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.