Evidence map›Paper›PMID 29682507›Full record

ArticleFrontiers in surgery2018

Bacterial Microbiome Dynamics in Post Pull-Through Hirschsprung-Associated Enterocolitis (HAEC): An Experimental Study Employing the Endothelin Receptor B-Null Mouse Model.

Zhi Cheng, Lifu Zhao, Deepti Dhall, Paul M Ruegger, James Borneman, Philip K Frykman

Open access · goldAbstract read
In one paragraph

Article in Frontiers in surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Update on the Pathogenesis of the Hirschsprung-Associated Enterocolitis.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Article
  10. Molecular medicine reports · 2022
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zhi ChengDivision of Pediatric Surgery and Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Lifu ZhaoDivision of Pediatric Surgery and Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Deepti DhallDepartment of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Paul M RueggerDepartment of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA, United States.
James BornemanDepartment of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA, United States.
Philip K FrykmanDivision of Pediatric Surgery and Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Cedars-Sinai Medical Center · USUniversity of California, Riverside · US

Funding

ET3-EDNRB Signaling in Enterocolitis Associated with Colonic AganglionosisK08DK090281 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI FRYKMAN, PHILIP KENT · 2011 to 2015
$755k
Bacterial and Fungal Dysbiosis in Hirschsprung-Associated EnterocolitisR03DK104040 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI FRYKMAN, PHILIP KENT · 2016 to 2017
$175k
NIDDK NIH HHS K08 DK090281NIDDK NIH HHS R03 DK104040
6 · The paper itself

Abstract

purposeHirschsprung-associated enterocolitis (HAEC) is the most frequent potentially life-threatening complication in children with Hirschsprung disease (HSCR) even after definitive corrective surgery. Mounting evidence suggests that intestinal microbiota likely contribute to the etiology of enterocolitis, so the aim of this study was to use a mouse model of post pull-through HAEC to compare the fecal bacterial communities of animals which developed HAEC to those free of enterocolitis.

methodsTen

resultsSix

conclusionsThis is the first study to identify

Indexed as

AkkermansiabacteroidetesHAEChirschsprung-associated enterocolitisHirschsprung enterocolitismicrobiomepull-through surgery

Identifiers

PMID29682507
PMCPMC5897423
OpenAlexW2795443006

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.