Evidence map›Paper›PMID 29682444›Full record

ArticleAnalytical cellular pathology (Amsterdam)2018

Molecular Detection of EMT Markers in Circulating Tumor Cells from Metastatic Non-Small Cell Lung Cancer Patients: Potential Role in Clinical Practice.

Annalisa Milano, Francesca Mazzetta, Sabatino Valente, Danilo Ranieri, Laura Leone, Andrea Botticelli, Concetta Elisa Onesti, Salvatore Lauro, Salvatore Raffa, Maria Rosaria Torrisi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical cellular pathology (Amsterdam), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Annalisa MilanoDepartment of Molecular and Clinical Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
Francesca MazzettaDepartment of Molecular and Clinical Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
Sabatino ValenteDepartment of Molecular and Clinical Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
Danilo RanieriDepartment of Molecular and Clinical Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
Laura LeoneDepartment of Molecular and Clinical Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
Andrea BotticelliDepartment of Molecular and Clinical Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
Concetta Elisa OnestiDepartment of Molecular and Clinical Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-8360-5026
Salvatore LauroDepartment of Molecular and Clinical Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
Salvatore RaffaDepartment of Molecular and Clinical Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-9501-7638
Maria Rosaria TorrisiDepartment of Molecular and Clinical Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
Paolo MarchettiDepartment of Molecular and Clinical Medicine, School of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNon-small cell lung cancer (NSCLC) is the most common cause of cancer-related mortality; nevertheless, there are few data regarding detection of circulating tumor cells (CTCs) in NSCLC, compared to other kinds of cancers in which their prognostic roles have already been defined. This difference is likely due to detection methods based on the epithelial marker expression which ignore CTCs undergoing epithelial-mesenchymal transition (CTCs

methodsAfter optimization of the test with spiking experiments of A549 cells undergoing TGF-

resultsRecovery experiments of spiked A549

conclusionsThe RT-PCR-based approach for the evaluation of CTCs

Indexed as

Epithelial-Mesenchymal TransitionPractice Patterns, Physicians'A549 CellsAgedBiomarkers, TumorCarcinoma, Non-Small-Cell LungCell CountFemaleHumansLung NeoplasmsMaleMiddle AgedNeoplasm MetastasisNeoplastic Cells, CirculatingPhenotypePrognosisBiomarkers, TumorTransforming Growth Factor beta1

Identifiers

PMID29682444
PMCPMC5848062
OpenAlexW2792487615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.