ReviewRMD open2018
Active discopathy: a clinical reality.
Review in RMD open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Steroids and L-Lysine Aescinate for Acute Radiculopathy Due to a Herniated Lumbar Disk.Medicina (Kaunas, Lithuania) · 2019Trial
- Pamidronate is ineffective for inflammatory-like low back pain associated with Modic type 1 changes: A double-blind, randomised controlled trial.Osteoarthritis and cartilage open · 2026Article
- Interaction of Dietary Patterns and Physical Activity with Low Back Pain in Pre- to Post-Menopause: A Cross-Sectional Study.Journal of health, population, and nutrition · 2026Article
- Article
- Efficacy of stepped care treatment for chronic discogenic low back pain patients with Modic I and II changes.Interventional pain medicine · 2023Article
- Are there any correlations among the number of discopathy levels and pain intensity or disability in patients with symptomatic low back pain?Archives of orthopaedic and trauma surgery · 2023Article
- Chronic Low Back Pain: A Narrative Review of Recent International Guidelines for Diagnosis and Conservative Treatment.Journal of clinical medicine · 2023Review
- Age and Sex in Back Pain Intensity-Retrospective Study of Conservatory vs. Surgical Discopathy Treatment.Life (Basel, Switzerland) · 2022Article
- Physiotherapeutic Methods in the Treatment of Cervical Discopathy and Degenerative Cervical Myelopathy: A Prospective Study.Life (Basel, Switzerland) · 2022Article
- Should Degenerated Intervertebral Discs of Patients with Modic Type 1 Changes Be Treated with Mesenchymal Stem Cells?International journal of molecular sciences · 2022Review
- Serum Biomarkers for Connective Tissue and Basement Membrane Remodeling are Associated with Vertebral Endplate Bone Marrow Lesions as Seen on MRI (Modic Changes).International journal of molecular sciences · 2020Article
- Serum biomarkers in people with chronic low back pain and Modic 1 changes: a case-control study.Scientific reports · 2019Article
- Is the discopathy associated with Modic changes an infectious process? Results from a prospective monocenter study.PloS one · 2019Article
- NTG-101: A Novel Molecular Therapy that Halts the Progression of Degenerative Disc Disease.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the late 1980s, the description by Modic and colleagues of elementary discovertebral changes detected on MRI (Modic classification) suggested for the first time a possible correlation between anatomical and clinical features in a subgroup of patients with non-specific chronic low back pain. Degenerative disc disease is frequent and usually asymptomatic, but Modic 1 changes in the vertebral endplates adjacent to a degenerated disc are associated with inflammatory-like chronic low back pain and low-grade local and systemic inflammation, which led to the concept of 'active discopathy'. Active discopathy shares some similarities with acute flares of peripheral osteoarthritis. Likewise, what triggers disc activation and how it self-limits remain unknown. A better understanding of mechanisms underlying disc activation and its self-limitation is of clinical relevance because it may enable the design of more targeted pharmacological and non-pharmacological interventions for the subgroup of patients with chronic low back pain and active discopathy. Here, we narratively review current disc-centred biomechanical and biochemical hypotheses of disc activation and discuss evidence of interactions with adverse personal and environmental factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.