ArticleVeterinary record open2018
Plasma procalcitonin concentrations are increased in dogs with sepsis.
Article in Veterinary record open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Septic Shock and Prognosis in Dogs and Cats With Sepsis-Consensus Definition and Clinical Criteria.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Pooled it
- Sepsis in Dogs and Cats-Consensus Definition and Clinical Criteria.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Pooled it
- Investigations of Procalcitonin, Interleukin-8 and Defensin-β in Dogs with Superficial and Deep Pyoderma.Veterinary sciences · 2026Article
- Diagnosis and surgical management of septic peritonitis in small animals: A review.Veterinary surgery : VS · 2026Review
- Plasma procalcitonin and C-reactive protein concentrations in dogs with bacterial sepsis and non-infectious systemic inflammatory response syndrome.Frontiers in veterinary science · 2025Article
- Regenerating island-derived protein 3E concentrations in healthy dogs and dogs with various inflammatory processes.PloS one · 2025Article
- Diagnosis of Septic Body Cavity Effusion in Dogs and Cats: Cytology vs. Bacterial Culture.Animals : an open access journal from MDPI · 2024Article
- Use of serum procalcitonin (PCT) level and PCT mRNA expression as a potential clinical biomarker in cats with bacterial and viral infections.Journal of feline medicine and surgery · 2022Article
- Serial analysis of blood biomarker concentrations in dogs with pneumonia, septic peritonitis, and pyometra.Journal of veterinary internal medicine · 2022Article
- Can Procalcitonin Be Dosed in Bovine Milk Using a Commercial ELISA Kit?Animals : an open access journal from MDPI · 2022Article
- Identification of regenerating island-derived protein 3E in dogs.Frontiers in veterinary science · 2022Article
- Comparison of clinical and inflammatory parameters in dogs with pyometra before and after ovariohysterectomy.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2021Article
- Comparison of Protein Carbonyl (PCO), Paraoxonase-1 (PON1) and C-Reactive Protein (CRP) as Diagnostic and Prognostic Markers of Septic Inflammation in Dogs.Veterinary sciences · 2021Article
- Comparison of C-reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia.Journal of veterinary internal medicine · 2021Article
- Evaluation and comparison of serum procalcitonin and heparin-binding protein levels as biomarkers of bacterial infection in cats.Journal of feline medicine and surgery · 2021Article
- Elevated Serum C1q Levels in Children With Sepsis.Frontiers in pediatrics · 2021Article
- Procalcitonin Detection in Veterinary Species: Investigation of Commercial ELISA Kits.Animals : an open access journal from MDPI · 2020Article
- Serum procalcitonin concentrations in dogs with induced endotoxemia.Journal of veterinary internal medicine · 2020Article
- Biomarker Guided Diagnosis of Septic Peritonitis in Dogs.Frontiers in veterinary science · 2019Article
- Agreement between Parallel Canine Blood and Urine Cultures: Is Urine Culture the Poor Man's Blood Culture?Journal of clinical microbiology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Sepsis, the life-threatening organ dysfunction caused by a dysregulated host response to infection, is difficult to identify and to prognosticate for. In people with sepsis, procalcitonin (PCT) measurement aids diagnosis, enables therapeutic monitoring and improves prognostic accuracy. This study used a commercial canine PCT assay to measure plasma PCT concentrations in dogs with gastric dilatation volvulus (GDV) syndrome and in dogs with sepsis. It was hypothesised that dogs with GDV syndrome and with sepsis have greater plasma PCT concentrations than healthy dogs and that dogs with sepsis have greater PCT concentrations than dogs with GDV syndrome. Before analysing canine plasma samples, the ability of the assay to identify canine PCT, in addition to assay imprecision and the lower limit of detection were established. The assay had low imprecision with coefficients of variation ≤4.5 per cent. The lower limit of detection was 3.4 pg/ml. Plasma PCT concentrations were measured in 20 dogs with sepsis, in 32 dogs with GDV syndrome and in 52 healthy dogs. Median (IQR) PCT concentration in dogs with sepsis 78.7 pg/ml (39.1-164.7) was significantly greater than in healthy dogs 49.8 pg/ml (36.2-63.7) (P=0.019), but there were no significant differences between PCT concentrations in dogs with GDV syndrome and controls (P=0.072) or between dogs with sepsis and GDV syndrome (P=1.000). Dogs with sepsis have significantly increased plasma PCT concentrations compared with healthy dogs, although considerable overlap between these populations was identified. Future investigations should confirm this finding in other populations and evaluate the diagnostic and prognostic value of PCT in dogs with sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.