Evidence map›Paper›PMID 29682221›Full record

ArticleAnnali di stomatologia

Mandible protraction alters Type I collagen, osteocalcin and osteonectin gene expression in adult mice condyle.

Patricia Valerio, Filipi Perfeito, Livia P Moura, Deborah N Ribeiro, Simone O A Fernandes, Almir S Martins, Maria F Leite

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annali di stomatologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Patricia ValerioDepartment of Physiology and Biophysics, Federal University of Minas Gerais, Brazil.
Filipi PerfeitoSchool of Pharmacy, Federal University of Minas Gerais, Brazil.
Livia P MouraDepartment of Physiology and Biophysics, Federal University of Minas Gerais, Brazil.
Deborah N RibeiroDepartment of Physiology and Biophysics, Federal University of Minas Gerais, Brazil.
Simone O A FernandesSchool of Pharmacy, Federal University of Minas Gerais, Brazil.
Almir S MartinsDepartment of Physiology and Biophysics, Federal University of Minas Gerais, Brazil.
Maria F LeiteDepartment of Physiology and Biophysics, Federal University of Minas Gerais, Brazil.
Universidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mandible condyle remodeling is a great challenge on craniofacial growth studies. The great majority of the reports deals with growing period. However, there is a great necessity to clarify the importance of functional stimulation on adult mandible condyle remodeling. By using an adult mouse model, we investigated the influence of mandible forwarding on condyle remodeling and gene expression by bone forming cells. Tomographic and scintigraphic evaluations showed sagittal growth and cell activity enhancement. RT-PCR showed that Type I collagen, osteocalcin and osteonectin expression level can be altered. We showed that functional stimulation is necessary to maintain the regular gene expression by condyle bone forming cells in adult mice. It opens new frame for further investigations aiming new clinical approaches to temporomandibular joint problems treatment, as well as mandible retrusion treatment.

Indexed as

bone biologycondyle growthCTgene expressiongrowth evaluationmolecular biology

Identifiers

PMID29682221
PMCPMC5897095
OpenAlexW2797504623

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.