Evidence map›Paper›PMID 29682218›Full record

ReviewOncotarget2018

Influence of physical exercise on microRNAs in skeletal muscle regeneration, aging and diseases.

Simona Ultimo, Giorgio Zauli, Alberto M Martelli, Marco Vitale, James A McCubrey, Silvano Capitani, Luca M Neri

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06083610 (Investigation of MicroRNA-1), which is not on this map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06083610 unknown statusnot on this mapstarted 2023, after this paper: background citation

Investigation of MicroRNA-1 (miRNA-1) and MicroRNA-133a (miRNA-133a) Levels After Acute Neuromuscular Exercise in Ultimate Frisbee Athletes

TypeobservationalSponsorYeditepe UniversityRan2023 to 2024Enrolled34ConditionsTo Determine the Levels of miRNA1 and miRNA133a Before and After ExerciseArmsmiRNA levels analysis from saliva samples
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 57 citations in OpenAlex.

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  13. Myotonic Dystrophy type 2 unmasked by physical activity resumption following COVID-19 lockdown: case discussion and review of the literature.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Simona UltimoDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Giorgio ZauliDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Alberto M MartelliDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Marco VitaleDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
James A McCubreyDepartment of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, USA.
Silvano CapitaniDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Luca M NeriDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
University of Ferrara · ITEast Carolina University · USUniversity of Bologna · ITUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle is a dynamic tissue with remarkable plasticity and its growth and regeneration are highly organized, with the activation of specific transcription factors, proliferative pathways and cytokines. The decline of skeletal muscle tissue with age, is one of the most important causes of functional loss of independence in older adults. Maintaining skeletal muscle function throughout the lifespan is a prerequisite for good health and independent living. Physical activity represents one of the most effective preventive agents for muscle decay in aging. Several studies have underlined the importance of microRNAs (miRNAs) in the control of myogenesis and of skeletal muscle regeneration and function. In this review, we reported an overview and recent advances about the role of miRNAs expressed in the skeletal muscle, miRNAs regulation by exercise in skeletal muscle, the consequences of different physical exercise training modalities in the skeletal muscle miRNA profile, their regulation under pathological conditions and the role of miRNAs in age-related muscle wasting. Specific miRNAs appear to be involved in response to different types of exercise and therefore to play an important role in muscle fiber identity and myofiber gene expression in adults and elder population. Understanding the roles and regulation of skeletal muscle miRNAs during muscle regeneration may result in new therapeutic approaches in aging or diseases with impaired muscle function or re-growth.

Indexed as

agingmiRNAsphysical activityregenerationskeletal muscle

Identifiers

PMID29682218
PMCPMC5908319
OpenAlexW2794973979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.