Evidence map›Paper›PMID 29682215›Full record

ReviewOncotarget2018

Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging.

Carolina Simioni, Giorgio Zauli, Alberto M Martelli, Marco Vitale, Gianni Sacchetti, Arianna Gonelli, Luca M Neri

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05592509 (Evaluation of the Antioxidant Effect of a Mixture of Ozonated Vegetable Oil and Vitamin Complex), which is not on this map. Cited by 242 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
242citing papers in PubMed, 10 pooled it
39.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05592509 nacompletednot on this mapstarted 2022, after this paper: background citation

Evaluation of the Antioxidant Effect of a Mixture of Ozonated Vegetable Oil and Vitamin Complex (Vitamin K2 and Vitamin B9) in Moderately Active Subjects With "Physical Activity Level" (LAF: 1.70-1.99): Pilot Study

TypeinterventionalSponsorS&R Farmaceutici S.p.A.Ran2022 to 2023Enrolled20ConditionsOxidative Stress, InflammationArmsOzonized vegetable oil with vitamines
3 · Its place in the literature

Who cites it

242 citing papers in PubMed, 10 syntheses or guidelines pooled it, 499 citations in OpenAlex.

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  8. Effect of Tai Chi on Markers of Oxidative Stress: Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021
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182 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Carolina SimioniDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Giorgio ZauliDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Alberto M MartelliDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Marco VitaleDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Gianni SacchettiDepartment of Life Sciences and Biotechnology, Pharmaceutical Biology Laboratory, University of Ferrara, Ferrara, Italy.
Arianna GonelliDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Luca M NeriDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
University of Ferrara · ITUniversity of Bologna · ITUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is nowadays seen as an indispensable element for good health, able to lower the risk of disorders of the cardiovascular, endocrine and osteomuscular apparatus, immune system diseases and the onset of potential neoplasms. A moderate and programmed physical exercise has often been reported to be therapeutic both in the adulthood and in aging, since capable to promote fitness. Regular exercise alleviates the negative effects caused by free radicals and offers many health benefits, including reduced risk of all-cause mortality, sarcopenia in the skeletal muscle, chronic disease, and premature death in elderly people. However, physical performance is also known to induce oxidative stress, inflammation, and muscle fatigue. Many efforts have been carried out to identify micronutrients and natural compounds, also known as nutraceuticals, able to prevent or attenuate the exercise-induced oxidative stress and inflammation. The aim of this review is to discuss the benefits deriving from a constant physical activity and by the intake of antioxidant compounds to protect the body from oxidative stress. The attention will be focused mainly on three natural antioxidants, which are quercetin, resveratrol and curcumin. Their properties and activity will be described, as well as their benefits on physical activity and on aging, which is expected to increase through the years and can get favorable benefits from a constant exercise activity.

Indexed as

agingantioxidant supplementationexercise trainingflavonoids intakenutraceuticals

Identifiers

PMID29682215
PMCPMC5908316
OpenAlexW2795223464

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.