Evidence map›Paper›PMID 29682214›Full record

ReviewOncotarget2018

Head and neck squamous cell carcinoma and its correlation with human papillomavirus in people living with HIV: a systematic review.

Manuela Ceccarelli, Emmanuele Venanzi Rullo, Alessio Facciolà, Giordano Madeddu, Bruno Cacopardo, Rosaria Taibi, Francesco D'Aleo, Marilia Rita Pinzone, Isa Picerno, Michele di Rosa and 4 more

Abstract readReview
In one paragraph

Review in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. CD8Frontiers in immunology · 2026
    Review
  7. Dysbiosis modulates CD8iScience · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Incidence and survival of HNSCC patients living with HIV compared with HIV-negative HNSCC patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
    Article
  15. How Much Does HIV Positivity Affect the Presence of Oral HPV? A Molecular Epidemiology Survey.International journal of environmental research and public health · 2021
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Manuela CeccarelliDepartment of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, Messina, Italy.
Emmanuele Venanzi RulloDepartment of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, Messina, Italy.
Alessio FacciolàDepartment of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, Messina, Italy.
Giordano MadedduDepartment of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Sassari, Sassari, Italy.
Bruno CacopardoDepartment of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Catania, Catania, Italy.
Rosaria TaibiDepartment of Medical Oncology A, National Cancer Institute of Aviano, Aviano, Italy.
Francesco D'AleoDepartment of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, Messina, Italy.
Marilia Rita PinzoneDepartment of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Isa PicernoDepartment of Biomedical and Dental Sciences and Morpho Functional Imaging, University of Messina, Messina, Italy.
Michele di RosaDepartment of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, University of Catania, Catania, Italy.
Giuseppa VisalliDepartment of Biomedical and Dental Sciences and Morpho Functional Imaging, University of Messina, Messina, Italy.
Fabrizio CondorelliDepartment of Pharmacological Sciences, Università del Piemonte Orientale "A. Avogadro", Novara, Italy.
Giuseppe NunnariDepartment of Clinical and Experimental Medicine, Unit of Infectious Diseases, University of Messina, Messina, Italy.
Giovanni Francesco PellicanòDepartment of Human Pathology of The Adult and The Developmental Age "G. Barresi", Unit of Infectious Diseases, University of Messina, Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the last 20 years we assisted to an increase in the mean age of People Living with HIV and their comorbidities. Especially, there was an increase in Human Papillomavirus-related head and neck squamous cell carcinomas. Despite their increasing incidence in HIV-positive people, mechanisms that lead to their development and progression are only partially understood. The aim of this review is to identify key data and factors about HPV-related head and neck squamous cell carcinoma in HIV-seropositive patients. Systematic search and review of the relevant literature-peer-reviewed and grey-was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. We included in our review only the 35 full-text articles we considered the most substantial. It is mandatory to improve our knowledge about the interactions existing between HPV and HIV, and about their actions on oral mucosa immune system.

Indexed as

head and neck cancerHIVHNSCCHPVpapillomavirus

Identifiers

PMID29682214
PMCPMC5908315

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.