Evidence map›Paper›PMID 29682166›Full record

ArticleOxidative medicine and cellular longevity2018

ROS-Induced DNA Damage Associates with Abundance of Mitochondrial DNA in White Blood Cells of the Untreated Schizophrenic Patients.

I V Chestkov, E M Jestkova, E S Ershova, V G Golimbet, T V Lezheiko, N Yu Kolesina, O A Dolgikh, V L Izhevskaya, G P Kostyuk, S I Kutsev and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  15. Toxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers.International journal of nanomedicine · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

I V ChestkovResearch Centre for Medical Genetics (RCMG), Moscow 115478, Russia.
E M JestkovaN. A. Alexeev Clinical Psychiatric Hospital №1 of Moscow Healthcare Department, Moscow 115447, Russia.
E S ErshovaResearch Centre for Medical Genetics (RCMG), Moscow 115478, Russia.
V G GolimbetMental Health Research Center, Moscow 115522, Russia.
T V LezheikoMental Health Research Center, Moscow 115522, Russia.
N Yu KolesinaMental Health Research Center, Moscow 115522, Russia.
O A DolgikhResearch Centre for Medical Genetics (RCMG), Moscow 115478, Russia.
V L IzhevskayaResearch Centre for Medical Genetics (RCMG), Moscow 115478, Russia.
G P KostyukN. A. Alexeev Clinical Psychiatric Hospital №1 of Moscow Healthcare Department, Moscow 115447, Russia.
S I KutsevResearch Centre for Medical Genetics (RCMG), Moscow 115478, Russia.
N N VeikoResearch Centre for Medical Genetics (RCMG), Moscow 115478, Russia.
S V KostyukMental Health Research Center, Moscow 115522, Russia.ORCID 0000-0003-2116-1244
Mental Health Research Center of Russian Academy of Medical Sciences · RUResearch Centre for Medical Genetics · RUMoscow Research and Clinical Center for Neuropsychiatry · RUV.A. Negovsky Scientific Research Institute of General Reanimatology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was (1) to examine the leukocyte mtDNA copy number (

methodsWe evaluated leukocyte mtDNA

resultsThe leukocyte mtDNA

conclusionThe leukocytes of the unmedicated SZ male patients with acute psychosis contain more mtDNA than the leukocytes of the male SZ patients treated with antipsychotic medications or the healthy controls. MtDNA content positively correlates with the level of 8-oxodG in the unmedicated SZ patients.

Indexed as

AdultDNA DamageDNA, MitochondrialFemaleFlow CytometryHumansLeukocytesLymphocytesMaleMiddle AgedReactive Oxygen SpeciesReal-Time Polymerase Chain ReactionSchizophreniaYoung AdultDNA, MitochondrialReactive Oxygen Species

Identifiers

PMID29682166
PMCPMC5845523
OpenAlexW2793006112

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.