ArticleOxidative medicine and cellular longevity2018
Age-Dependent Protective Effect of Selenium against UVA Irradiation in Primary Human Keratinocytes and the Associated DNA Repair Signature.
Article in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders.Current medicinal chemistry · 2025Review
- Selenized Chickpea Sprouts Hydrolysates as a Potential Anti-Aging Ingredient.Molecules (Basel, Switzerland) · 2023Article
- On the Potential Role of the Antioxidant Couple Vitamin E/Selenium Taken by the Oral Route in Skin and Hair Health.Antioxidants (Basel, Switzerland) · 2022Review
- FermentedFood science & nutrition · 2022Article
- Osmotic Stress Interferes with DNA Damage Response and H2AX Phosphorylation in Human Keratinocytes.Cells · 2022Article
- Antitumor Effects of Selenium.International journal of molecular sciences · 2021Review
- Chemical Composition and Protective Effect of Young Barley (Antioxidants (Basel, Switzerland) · 2021Article
- Selenium as a Bioactive Micronutrient in the Human Diet and Its Cancer Chemopreventive Activity.Nutrients · 2021Review
- Article
- Bioactive Compounds for Skin Health: A Review.Nutrients · 2021Review
- Nutrition Can Help DNA Repair in the Case of Aging.Nutrients · 2020Review
- The effect of vitamin E and selenium combination in repairing fluoride-induced DNA damage to NRK-52E cells.Molecular biology reports · 2020Article
- Genome-Protecting Compounds as Potential Geroprotectors.International journal of molecular sciences · 2020Review
- Prospective Evaluation of the Efficacy of a Food Supplement in Increasing Photoprotection and Improving Selective Markers Related to Skin Photo-Ageing.Dermatology and therapy · 2020Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Few studies have focused on the protective role of selenium (Se) against skin aging and photoaging even though selenoproteins are essential for keratinocyte function and skin development. To the best of our knowledge, the impact of Se supplementation on skin cells from elderly and young donors has not been reported. Therefore, the main objective of our study was to evaluate the effects of Se supplementation on skin keratinocytes at baseline and after exposure to ultraviolet A (UVA) irradiation. Low doses of Se (30 nM) were very potently protective against UVA-induced cytotoxicity in young keratinocytes, whereas the protection efficiency of Se in old keratinocytes required higher concentrations (240 nM). Additionally, the DNA repair ability of the old keratinocytes drastically decreased compared with that of the young keratinocytes at baseline and after the UVA exposure. The Se supplementation significantly enhanced the DNA repair of 8-oxoguanine (8oxoG) only in the keratinocytes isolated from young donors. Therefore, aged keratinocytes have an increased vulnerability to oxidative DNA damage, and the Se needs in the elderly should be considered. Strengthening DNA repair activities with Se supplementation may represent a new strategy to combat aging and skin photoaging.
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