Evidence map›Paper›PMID 29681947›Full record

ArticleStem cells international2018

Synergistic Integration of Mesenchymal Stem Cells and Hydrostatic Pressure in the Expansion and Maintenance of Human Hematopoietic/Progenitor Cells.

Yun Gyeong Kang, Jee-Yeong Jeong, Tae-Hee Lee, Ho Sup Lee, Jung-Woog Shin

Abstract read
In one paragraph

Article in Stem cells international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yun Gyeong KangDepartment of Biomedical Engineering, Inje University, Gimhae, Gyeongsangnam-do, Republic of Korea.ORCID 0000-0002-1882-0854
Jee-Yeong JeongDepartment of Biochemistry and Cancer Research Institute, Kosin University College of Medicine, Busan, Republic of Korea.ORCID 0000-0001-9482-4526
Tae-Hee LeeLaboratory for Cancer & Stem Cell Biology, Plant Engineering Institute, Sejong University, Seoul, Republic of Korea.ORCID 0000-0003-3750-9102
Ho Sup LeeDepartment of Internal Medicine, Kosin University College of Medicine, Busan, Republic of Korea.ORCID 0000-0001-5974-6884
Jung-Woog ShinDepartment of Biomedical Engineering, Inje University, Gimhae, Gyeongsangnam-do, Republic of Korea.ORCID 0000-0003-1047-9871

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ex vivo expansion of hematopoietic stem/progenitor cell (HSPC) has been investigated to improve the clinical outcome of HSPC transplantation. However, ex vivo expansion of HSPCs still faces a major obstacle in that HPSCs tend to differentiate when proliferating. Here, we cocultured HSPCs with mesenchymal stem cells (MSCs) and divided the HSPCs into two fractions according to whether they came into adherent to MSCs or not. Additionally, we used hydrostatic pressure (HP) to mimic the physical conditions

Identifiers

PMID29681947
PMCPMC5848107

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.