ArticleCurrent gerontology and geriatrics research2018
Development of a Physiological Frailty Index for the World Trade Center General Responder Cohort.
Article in Current gerontology and geriatrics research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The frailty index based on laboratory test data as a tool to investigate the impact of frailty on health outcomes: a systematic review and meta-analysis.Age and ageing · 2023Pooled it
- Urban exposures, frailty, and mental illness in World Trade Center Health Program responders.Nature communications · 2026Article
- Urban Exposures, Frailty, and Mental Illness in World Trade Center Health Program Responders.medRxiv : the preprint server for health sciences · 2026Article
- Article
- A pilot study to identify factors associated with frailty within the World Trade Center general responder cohort.American journal of industrial medicine · 2024Article
- Comparing frailty prevalence between countries: validation of the Global Burden of Disease study Frailty Index (GBD-FI) in the survey of health, ageing and retirement in Europe.Age and ageing · 2023Article
- Impact of preoperative laboratory frailty index on mortality and clinical outcomes in older surgical patients with cancer.Scientific reports · 2022Article
- Frailty indices based on self-report, blood-based biomarkers and examination-based data in the Canadian Longitudinal Study on Aging.Age and ageing · 2022Article
- Cognitive impairment and World Trade Centre-related exposures.Nature reviews. Neurology · 2022Review
- Complementing chronic frailty assessment at hospital admission with an electronic frailty index (FI-Laboratory) comprising routine blood test results.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020Article
- An Assessment of Long-Term Physical and Emotional Quality of Life of Persons Injured on 9/11/2001.International journal of environmental research and public health · 2019Article
- Development and Validation of a Clinical Frailty Index for the World Trade Center General Responder Cohort.Journal of aging and healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Responders to the 9/11/2001 WTC attacks were exposed to multiple toxic pollutants. Since 2002, the health of the responder cohort has been continuously tracked by the WTC Health Monitoring Program. However, no assessments have been made of frailty, an important health metric given the current average age of the WTC responder cohort (55 years). In this study, we use laboratory test results and other physiological parameters to construct a physiological frailty index (FI-Lab) for this cohort. The study sample comprised responders aged 40 years or older who completed a health monitoring visit at Mount Sinai Center within the past 5 years. For each subject, FI-Lab was computed as the proportion of 20 physiological parameters (lab tests, pulmonary function, and blood pressure) on which the subject had abnormal values. Using negative binomial regression models, we tested FI-Lab's association with the SF-12 wellbeing score and various demographic characteristics. FI-Lab showed strong associations with the physical and mental components of the SF-12 as well as age, race, and smoking status. Using a cutoff of 0.25 to define presence of physiological/preclinical frailty, we found frailty prevalence in the study sample to be approximately 12%. This study demonstrates the feasibility of assessing preclinical frailty in the WTC responder cohort.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.