ArticleCase reports in oncology
Non-Gestational Choriocarcinoma with Widespread Metastases Presenting with Type 1 Respiratory Failure in a 39-Year-Old Female: Case Report and Review of the Literature.
Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Repurposing metformin for choriocarcinoma: targeting the AMPK/mTOR pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- A Rare Case of Primary Pulmonary Choriocarcinoma Metastasizing to the Kidney: Diagnostic and Therapeutic Complexities.Cancer reports (Hoboken, N.J.) · 2026Article
- Gestational trophoblastic neoplasia with pancreatic metastasis: clinical characteristics, treatment strategies, and outcomes.Orphanet journal of rare diseases · 2025Article
- Gestational choriocarcinoma FIGO stage III, score 8 (high-risk) in 38-year-old woman four weeks postpartum.Case reports in perinatal medicine · 2025Article
- Male choriocarcinoma presenting with intracerebral hemorrhage: a case report and literature review.Frontiers in oncology · 2025Article
- Primary Pulmonary Choriocarcinoma With Lymph Node Metastasis: A Case Report and Brief Review.Cureus · 2024Article
- Potential diagnostic challenges of intracerebral hemorrhage as an index presentation of metastatic choriocarcinoma: A case series.Clinical case reports · 2024Article
- Revealing the Unanticipated: An Uncommon Case of Colorectal Adenocarcinoma Transitioning to Choriocarcinoma - A Case Report and Literature Review.European journal of case reports in internal medicine · 2024Article
- Article
- Choriocarcinoma complicated with intra-abdominal and intrapleural hemorrhage in pregnancy - case report.Frontiers in oncology · 2023Article
- Non-Gestational Ovarian Choriocarcinoma: A Rare Ovarian Cancer Subtype.Diagnostics (Basel, Switzerland) · 2022Review
- Clinical Experience of Male Primary Choriocarcinoma at the Samsung Medical Center.Cancer research and treatment · 2021Article
- An Overview of the Role of Long Non-Coding RNAs in Human Choriocarcinoma.International journal of molecular sciences · 2021Review
- Haemoptysis in third trimester-sole manifestation of stage IV gestational choriocarcinoma.BMJ case reports · 2021Article
- Article
- When a Differential Diagnosis Is Fundamental: Choriocarcinoma Mimicking Lung Carcinoma.Journal of clinical medicine · 2019Article
- A Transplantable Syngeneic Allograft Mouse Model for Nongestational Choriocarcinoma of the Ovary.Veterinary pathology · 2019Article
- Gestational trophoblastic diseases - literature review and atypical case reports.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
- Metastasis of Testicular Choriocarcinoma in the Stomach, Complicated by the Development of Choriocarcinoma Syndrome.Case reports in gastroenterologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionNon-gestational choriocarcinoma (NGCC) is an extremely rare cancer. We report a case presenting in extremis. CASE REPORT: A 39-year-old woman presented with type 1 respiratory failure with a 1-month history of breathlessness. Computed tomography (CT) revealed widespread metastatic disease involving the lungs, liver, pancreas, and breast. Serum β-human chorionic gonadotropin was markedly raised. Over 72 h, she deteriorated and was started on high-flow nasal cannula to facilitate discussions and for comfort. Histology from a breast biopsy suggested a choriocarcinoma, and she was commenced on etoposide and cisplatin. Unfortunately she continued to deteriorate and died on day 11 of admission. Molecular genotyping received post-mortem confirmed non-gestational choriocarcinomatous differentiation within a high-grade tumour. DISCUSSION: NGCC carries a worse prognosis compared with gestational choriocarcinoma and is historically less chemosensitive. However, differentiation between these two diagnoses is challenging due to a lack of immuno-histochemical differences. The NGCC in this case was likely to have originated in the lung due to a 12-cm mass in the lingula, and extensive emphysema on CT. Primary pulmonary choriocarcinoma has a rapidly fatal course in the majority of patients.
conclusionThis is the only case to our knowledge of NGCC presenting in extremis, where an accurate diagnosis was not achieved pre-mortem. This also demonstrates the merit of non-invasive ventilation within palliation to facilitate communication and comfort.
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