ArticleFrontiers in molecular neuroscience2018
ATF3 Regulates the Expression of AChE During Stress.
Article in Frontiers in molecular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 6 citations in OpenAlex.
- Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Combination effect of exercise training and eugenol supplementation on the hippocampus apoptosis induced by chlorpyrifos.Molecular biology reports · 2020Article
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8 authors at 2 institutions in 1 country.
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Abstract
Acetylcholinesterase (AChE) expresses in non-cholinergic cells, but its role(s) there remain unknown. We have previously attributed a pro-apoptotic role for AChE in stressed retinal photoreceptors, though by unknown mechanism. Here, we examined its promoter only to find that it includes a binding sequence for the activating transcription factor 3 (ATF3); a prototypical mediator of apoptosis. This suggests that expression of AChE could be regulated by ATF3 in the retina. Indeed, ATF3 binds the AChE-promoter to down-regulate its expressions
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