ArticleJournal of human reproductive sciences
Possible Link Between Stress-related Factors and Altered Body Composition in Women with Polycystic Ovarian Syndrome.
Article in Journal of human reproductive sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
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Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
- Review
- Effects of digital health education intervention on stress, anxiety and depression of patients with polycystic ovarian syndrome: study protocol for a single blinded randomized controlled trial.AIMS public health · 2026Article
- Vitamin D Deficiency and VDR Gene Variants in Polycystic Ovary Syndrome: A Case-Control Study.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Review
- Article
- Stress responses to bacterial and viral mimetics in polycystic ovary syndrome model rats.Brain, behavior, & immunity - health · 2024Article
- Developing a Novel Web-Based Self-Management Support Intervention for Polycystic Ovary Syndrome: Mixed Methods Study With Patients and Health Care Professionals.JMIR formative research · 2024Article
- Mitochondrial DNA copy number variation and gene mutations mediate polycystic ovary syndrome: research progress.American journal of translational research · 2024Review
- Article
- Acute iv CRH administration significantly increases serum active ghrelin in postmenopausal PCOS women compared to postmenopausal controls.Endocrine · 2023Article
- Article
- A narrative review of the physiology and health effects of burnout associated with veterinarian-pertinent occupational stressors.Frontiers in veterinary science · 2023Review
- A case-control study about markers of stress in normal-/overweight women with polycystic ovary syndrome and in controls.Frontiers in endocrinology · 2023Article
- The interplay of oxidative stress and immune dysfunction in Hashimoto's thyroiditis and polycystic ovary syndrome: a comprehensive review.Frontiers in immunology · 2023Review
- PCOS and Depression: Common Links and Potential Targets.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Association of -675 4G/5G PAI-1 and -2518A/G MCP-1 genetic polymorphisms with polycystic ovary syndrome in Kashmiri women: A case control study.Journal of family medicine and primary care · 2022Article
- Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment.International journal of environmental research and public health · 2022Review
- Role of polycystic ovarian syndrome in developing psychological burden in Saudi Arabian females: A case control study.Frontiers in public health · 2022Article
- Assessment of prevalence, knowledge of polycystic ovary syndrome and health-related practices among women in klang valley: A cross-sectional survey.Frontiers in endocrinology · 2022Article
- Associations Between Asthma and Polycystic Ovary Syndrome: Current Perspectives.Frontiers in endocrinology · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStress is an invisible factor affecting modern day living and is strongly associated with many disease pathogenesis including polycystic ovarian syndrome (PCOS) in women. PCOS is the most frequent endocrinological disorder that affects women of reproductive age, leading to metabolic dysfunction and body composition alterations. Salivary amylase and cortisol are major stress mediators that have been implicated in PCOS. However, their role in altering body composition in PCOS is yet to be deciphered.
aimThe present study aimed at understanding the relation between stress-associated factors and alterations in body composition among PCOS patients.
designThis study enrolled a total of 100 patients (PCOS) and 60 age-matched controls. The female patients were of ages between 13 and 30 years. MATERIALS AND
methodsStandard assay kits were used to evaluate the α-amylase activity and cortisol level in saliva. The participants were chosen on the basis of the Rotterdam American Society for Reproductive Medicine/European Society of Human Reproduction criteria. Saliva was collected from each participant as per the protocol of Salimetrics, USA. STATISTICAL ANALYSIS: Statistical analysis was performed using SPSS version 20 for Windows. The quantitative variables are described as mean ± standard deviation.
resultsIncreased salivary cortisol level and α-amylase activity were seen in the PCOS population as compared to age-matched controls suggesting patients a sustained stress scenario in their system. Moreover, overweight PCOS participants reflected higher amylase activity than the lean patients participants. Pulse rate, body mass index (BMI), visceral adiposity, and waist-hip ratio (WHR) was considerably higher in the PCOS patients participants compared to controls. A significant correlation could be drawn between the α-amylase activity and BMI or WHR, respectively, among PCOS patients. These observations indicate a strong link between the stress marker and alterations in the body composition parameters of PCOS patients participants.
conclusionHigher prevalence of stress in PCOS patients participants has a critical role in their altered body composition.
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Registered trials
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