Evidence map›Paper›PMID 29681660›Full record

ArticleMonatshefte fur chemie2018

Synthesis of novel ligands targeting phenazine biosynthesis proteins as a strategy for antibiotic intervention.

Nikolaus Guttenberger, Thomas Schlatzer, Mario Leypold, Sebastian Tassoti, Rolf Breinbauer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Monatshefte fur chemie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Amoebicidal effect of pyocyanin and its mechanism of action againstCurrent research in parasitology & vector-borne diseases · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nikolaus GuttenbergerInstitute of Organic Chemistry, Graz University of Technology, Graz, Austria.
Thomas SchlatzerInstitute of Organic Chemistry, Graz University of Technology, Graz, Austria.
Mario LeypoldInstitute of Organic Chemistry, Graz University of Technology, Graz, Austria.
Sebastian TassotiInstitute of Organic Chemistry, Graz University of Technology, Graz, Austria.
Rolf BreinbauerInstitute of Organic Chemistry, Graz University of Technology, Graz, Austria.ORCID 0000-0001-6009-7359

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractIn this contribution, we report synthetic strategies towards potential ligands for the study of binding differences between PhzE, the first enzyme in the biosynthesis of phenazines, and the related enzyme anthranilate synthase. The ligands were designed with the overriding goal to develop new antibiotics via downregulation of phenazine biosynthesis. GRAPHICAL ABSTRACT:

Indexed as

AntibioticsEnzymesEtherificationInhibitorPhenazines

Identifiers

PMID29681660
PMCPMC5906492

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.