ArticleTranslational psychiatry2018
Analysis of 182 cerebral palsy transcriptomes points to dysregulation of trophic signalling pathways and overlap with autism.
Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Integrating genome and RNA sequencing to enhance diagnostic precision in cerebral palsy.BMC pediatrics · 2026Article
- HUWE1 regulates mitophagy to protect dopaminergic neurons from 6-OHDA- and MPP⁺-induced neurotoxicity.Cell biology and toxicology · 2026Article
- Review
- Exome sequencing reveals genetic heterogeneity and clinically actionable findings in children with cerebral palsy.Nature medicine · 2024Article
- Redefining cerebral palsies as a diverse group of neurodevelopmental disorders with genetic aetiology.Nature reviews. Neurology · 2023Review
- Integrative Multi-Omics Research in Cerebral Palsy: Current Progress and Future Prospects.Neurochemical research · 2023Review
- Genome-wide analysis of transcription factors in hippocampal tissue of cerebral palsy rats after acupuncture treatment.American journal of translational research · 2023Article
- Dysregulation of multiple signaling pathways: A possible cause of cerebral palsy.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Allostery, and how to define and measure signal transduction.Biophysical chemistry · 2022Review
- Navigating the pitfalls of applying machine learning in genomics.Nature reviews. Genetics · 2022Review
- How can same-gene mutations promote both cancer and developmental disorders?Science advances · 2022Article
- Genetic testing in individuals with cerebral palsy.Developmental medicine and child neurology · 2021Article
- Immunological effects of cerebral palsy and rehabilitation exercises in children.Brain, behavior, & immunity - health · 2021Article
- Multiomic analysis elucidates Complex I deficiency caused by a deep intronic variant in NDUFB10.Human mutation · 2021Article
- Mutations disrupting neuritogenesis genes confer risk for cerebral palsy.Nature genetics · 2020Article
- Insights From Genetic Studies of Cerebral Palsy.Frontiers in neurology · 2020Review
- Deep Learning/Artificial Intelligence and Blood-Based DNA Epigenomic Prediction of Cerebral Palsy.International journal of molecular sciences · 2019Article
- Family History of Mental and Neurological Disorders and Risk of Autism.JAMA network open · 2019Article
- Pathogenic copy number variants that affect gene expression contribute to genomic burden in cerebral palsy.NPJ genomic medicine · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral palsy (CP) is the most common motor disability of childhood. It is characterised by permanent, non-progressive but not unchanging problems with movement, posture and motor function, with a highly heterogeneous clinical spectrum and frequent neurodevelopmental comorbidities. The aetiology of CP is poorly understood, despite recent reports of a genetic contribution in some cases. Here we demonstrate transcriptional dysregulation of trophic signalling pathways in patient-derived cell lines from an unselected cohort of 182 CP-affected individuals using both differential expression analysis and weighted gene co-expression network analysis (WGCNA). We also show that genes differentially expressed in CP, as well as network modules significantly correlated with CP status, are enriched for genes associated with ASD. Combining transcriptome and whole exome sequencing (WES) data for this CP cohort likely resolves an additional 5% of cases separated to the 14% we have previously reported as resolved by WES. Collectively, these results support a convergent molecular abnormality in CP and ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.