Evidence map›Paper›PMID 29681528›Full record

ArticleThe Knee2018

Local associations between knee cartilage T

Hsiang-Ling Teng, Valentina Pedoia, Thomas M Link, Sharmila Majumdar, Richard B Souza

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Knee, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Comparison of Dynamic Knee Contact Mechanics with TAnnals of biomedical engineering · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Longitudinal analysis of the contribution of 3D patella and trochlear bone shape on patellofemoral joint osteoarthritic features.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Hsiang-Ling TengMusculoskeletal Quantitative Imaging Research Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry Street, San Francisco, CA, USA; Department of Physical Therapy, California State University, Long Beach, 1250 Bellflower Boulevard, Long Beach, CA, USA. Electronic address: Hsiang-Ling.Teng@csulb.edu.
Valentina PedoiaMusculoskeletal Quantitative Imaging Research Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry Street, San Francisco, CA, USA.
Thomas M LinkMusculoskeletal Quantitative Imaging Research Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry Street, San Francisco, CA, USA.
Sharmila MajumdarMusculoskeletal Quantitative Imaging Research Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry Street, San Francisco, CA, USA.
Richard B SouzaMusculoskeletal Quantitative Imaging Research Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry Street, San Francisco, CA, USA; Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, 1500 Owens Street, San Francisco, CA, USA.
University of California, San Francisco · USAmerican Physical Therapy Association · USCalifornia State University, Long Beach · US

Funding

MRI TO STUDY CARTILAGE/BONE INTERACTIONSR01AR046905 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 1999 to 2015
$6.3M
Translation of Quantitative Imaging in OsteoarthritisP50AR060752 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANE, NANCY E · 2011 to 2015
$6.2M
Mentoring Biomechanics Research in OsteoarthritisK24AR072133 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Richard Brian Souza · 2018 to 2026
$1.5M
Contact mechanics, neuromuscular control, and cartilage composition in knee OAR01AR062370 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOUZA, RICHARD BRIAN · 2011 to 2014
$1.1M
NIAMS NIH HHS K24 AR072133NIAMS NIH HHS P50 AR060752NIAMS NIH HHS R01 AR046905NIAMS NIH HHS R01 AR062370
6 · The paper itself

Abstract

backgroundThis study aimed to utilize voxel-based relaxometry (VBR) to examine local correlations between patellofemoral joint (PFJ) stress during gait and PFJ cartilage relaxation times.

methodsEighty-three subjects with and without PFJ osteoarthritis (OA) underwent knee magnetic resonance (MR) images using fast spin-echo, T1ρ and T2 relaxation time sequences. Patellar and trochlear cartilage relaxation times were computed for each voxel. Peak PFJ stress was computed during the stance phase from three-dimensional gait analysis. Statistical Parametric Mapping was used to perform VBR analyses. Pearson partial correlations were used to evaluate the associations between peak PFJ stress and cartilage relaxation times while controlling for age, sex, and body mass index.

resultsA higher percentage of the trochlear cartilage (15.9-29.1%) showed significant positive correlations between PFJ stress and T1ρ and T2 than the patellar cartilage (7.4-13.6%). Average correlation coefficient (R) of the voxels showing significant positive correlations ranged from 0.27 to 0.29. Subcompartment analysis revealed a higher percentage of lateral compartment cartilage (trochlea: 30.2-34.7%, patella: 8.1-14.8%) showed significant correlations between peak PFJ stress and T1ρ and T2 than the medial compartment cartilage (trochlea: 7.1-27.2%, patella: 5.5-5.9%). Subgroup analysis showed that larger percentages of PFJ cartilage demonstrated significant positive correlations with PFJ stress in subjects with PFJ OA than those without PFJ OA.

conclusionsThe findings of this study suggest that peak PFJ stress has a greater influence on the biochemical composition of the trochlear than the patellar cartilage, and the lateral than the medial PFJ compartment.

Indexed as

Biomechanical PhenomenaCartilage, ArticularFemaleGaitHumansImaging, Three-DimensionalKneeKnee JointMagnetic Resonance ImagingMaleMiddle AgedOsteoarthritis, KneePatellaPatellofemoral JointTime and Motion StudiesWalkingGaitMagnetic resonance imagingPatellofemoral jointRelaxation time

Identifiers

PMID29681528
PMCPMC6049815
OpenAlexW2802828138

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.