ArticleCancer cell2018
Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia.
Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Cancer cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00137111 (Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia), which is not on this map. Cited by 124 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 1 pooled it
23.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia
Who cites it
124 citing papers in PubMed, 1 synthesis or guideline pooled it, 203 citations in OpenAlex.
- Prevalence and prognostic significance of IKZF1 deletion in paediatric acute lymphoblastic leukemia: A systematic review and meta-analysis.Annals of hematology · 2023Pooled it
- Germ line genetic NBN variation and predisposition to B-cell acute lymphoblastic leukemia in children.Blood · 2024Trial
- A genomic and epigenomic lens into the biology of acute lymphoblastic leukaemia.Nature reviews. Cancer · 2026Review
- Genetic influences on haematopoiesis.Nature reviews. Genetics · 2026Review
- Systematic functional validation of IKAROS variants from patients and laboratory-generated mutations.Blood advances · 2026Article
- Status of IKZF1 Deletions in Diagnose and Relapsed Pediatric B-ALL Patients.Biochemical genetics · 2026Article
- Long-term trends in the burden of leukemia subtypes in China from 1990 to 2021: a Joinpoint regression and age-period-cohort analysis based on GBD 2021.Frontiers in medicine · 2026Article
- Review
- Reprogramming lineage features promotes epithelial behavior in carcinoma cells.Cancer letters · 2026Article
- IKAROS Gene Regulatory Network Reveal ERG as a Vulnerability in B-cell Acute Lymphoblastic Leukemia.bioRxiv : the preprint server for biology · 2025Article
- Human Cancers Derived from Either Genetic or Lifestyle Factors Are Initiated by Impaired Estrogen Signaling.Cancers · 2025Review
- Article
- Inborn errors of regulatory T-cell differentiation and function.The Journal of allergy and clinical immunology · 2025Review
- Genetic susceptibility ofGlobal medical genetics · 2025Article
- Review
- The IKAROS Transcription Factor Gene IKZF1 as a Critical Regulator in the Pathogenesis of Childhood Acute Lymphoblastic Leukemia: Insights from a Bangladeshi Population.Indian journal of clinical biochemistry : IJCB · 2025Article
- IKZF-associated inborn errors of immunity.Journal of human immunity · 2025Review
- Human genetic influences on early B cell development.Journal of human immunity · 2025Review
- Discovery of a germline IKZF1 deletion in a B-lymphoblastic leukemia post-induction bone marrow specimen: a case report and review of the literature.Journal of hematopathology · 2025Review
- Review
64 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
36 authors at 15 institutions in 4 countries.
Michelle L ChurchmanDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Maoxiang QianDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Geertruy Te KronnieDepartment of Women's and Children's Health, University of Padova, 35128 Padova, Italy.
Ranran ZhangDepartment of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120 Guangdong, China.
Wenjian YangDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Hui ZhangDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120 Guangdong, China.
Tobia LanaDepartment of Women's and Children's Health, University of Padova, 35128 Padova, Italy.
Paige TedrickDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Rebekah BaskinDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Katherine VerbistDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jennifer L PetersCellular Imaging Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Meenakshi DevidasDepartment of Biostatistics, Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Eric LarsenMaine Children's Cancer Program, Scarborough, ME 04074, USA.
Ian M MooreDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Zhaohui GuDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Chunxu QuDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Hiroki YoshiharaDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Shaina N PorterCenter for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Shondra M Pruett-MillerCenter for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Gang WuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Elizabeth RaetzDivision of Pediatric Hematology-Oncology, New York University, New York, NY 10016, USA.
Paul L MartinDepartment of Pediatrics, Duke University, Durham, NC 27708, USA.
W Paul BowmanCook Children's Medical Center, Fort Worth, TX 76104, USA.
Naomi WinickPediatric Hematology Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Elaine MardisInstitute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Robert FultonMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA.
Martin StanullaPediatric Hematology and Oncology, Hannover Medical School, Hannover 30625, Germany.
William E EvansDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Mary V RellingDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Ching-Hon PuiDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Stephen P HungerDepartment of Pediatrics and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Mignon L LohDepartment of Pediatrics, Benioff Children's Hospital and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158, USA.
Rupert HandgretingerDepartment of Hematology/Oncology, Children's University Hospital, 72076 Tuebingen, Germany.
Kim E NicholsDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jun J YangDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: jun.yang@stjude.org.
Charles G MullighanDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Hematological Malignancies Program, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: charles.mullighan@stjude.org.
St. Jude Children's Research Hospital · USUniversity of Padua · ITChildren's Hospital of Philadelphia · USCook Children's Medical Center · USDuke University · USFirst Affiliated Hospital of Guangzhou Medical University · CNJames S. McDonnell Foundation · USMedizinische Hochschule Hannover · DENationwide Children's Hospital · USNew England Cancer Specialists · USNew York University · USThe University of Texas Southwestern Medical Center · USUniversity Children's Hospital Tübingen · DEUniversity of California, San Francisco · USUniversity of Florida · US
Funding
NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6MCOG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5MViral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MCOG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8MTranslational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3MChildren's Oncology Group Statistics &Data Center GrantU10CA098413 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DEVIDAS, MEENAKSHI · 2003 to 2013
$67.5MCPML - Project 3: Genome-wide Studies of Adverse EffectsP50GM115279 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI LOH, MIGNON LEE-CHEUN, RELLING, MARY V · 2015 to 2019
$15.1MSupport for Human Specimen Banking in NCI-Supported Cancer Clinical TrialsU24CA114766 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI RAMIREZ MILAN, NILSA DEL CARMEN · 2005 to 2014
$14.5MTranslating genomic discoveries to improved outcomes for high risk acute leukemiaR35CA197695 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Charles G Mullighan · 2017 to 2026
$11.4MPharmacogenomics of Childhood Leukemia ALLR01CA036401 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI EVANS, WILLIAM E · 1985 to 2019
$3.6MARID5B and disparities of childhood leukemiaU01CA176063 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI YANG, JUN J. · 2014 to 2018
$2.4MNCI NIH HHS P30 CA016058NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA036401NCI NIH HHS R35 CA197695NCI NIH HHS U01 CA176063NCI NIH HHS U10 CA098413NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NCI NIH HHS U24 CA114766NIGMS NIH HHS P50 GM115279
Abstract
Somatic genetic alterations of IKZF1, which encodes the lymphoid transcription factor IKAROS, are common in high-risk B-progenitor acute lymphoblastic leukemia (ALL) and are associated with poor prognosis. Such alterations result in the acquisition of stem cell-like features, overexpression of adhesion molecules causing aberrant cell-cell and cell-stroma interaction, and decreased sensitivity to tyrosine kinase inhibitors. Here we report coding germline IKZF1 variation in familial childhood ALL and 0.9% of presumed sporadic B-ALL, identifying 28 unique variants in 45 children. The majority of variants adversely affected IKZF1 function and drug responsiveness of leukemic cells. These results identify IKZF1 as a leukemia predisposition gene, and emphasize the importance of germline genetic variation in the development of both familial and sporadic ALL.
Indexed as
Germ-Line MutationAnimalsChildFemaleFrameshift MutationGenetic Predisposition to DiseaseHumansIkaros Transcription FactorMaleMiceNeoplasm TransplantationPedigreePrecursor B-Cell Lymphoblastic Leukemia-LymphomaSequence Analysis, DNAIkaros Transcription FactorIKZF1 protein, humanacute lymphoblastic leukemiaALLdrug responsefamilial leukemiagermline genetic variationIKAROSIKZF1immunodeficiencypredisposition
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Registered trials
NCT00137111ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.