Evidence map›Paper›PMID 29681485›Full record

ArticleBioorganic & medicinal chemistry2018

Investigation of transition metal-catalyzed nitrene transfer reactions in water.

Juliet M Alderson, Joshua R Corbin, Jennifer M Schomaker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Bifunctional Aziridines from Photochemically Generated FSOAngewandte Chemie (International ed. in English) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Juliet M AldersonDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706 USA.
Joshua R CorbinDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706 USA.
Jennifer M SchomakerDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706 USA. Electronic address: schomakerj@chem.wisc.edu.

Funding

TR&D 3: TECHNOLOGY DEVELOPMENT FOR NMR STUDIES OF SMALL MOLECULES (METABOLOMICS, NATURAL PRODUCTS, METABOLITE-PROTEIN INTERACTIONS) pp.537-585 P41GM103399 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 2012 to 2019
$9.4M
Upgrade of the NMRFAM 750 MHz NMR SpectrometerS10RR029220 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 2010 to 2010
$766k
QExactive (Orbitrap) mass spectrometerS10OD020022 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI VESTLING, MARTHA M · 2015 to 2015
$483k
NMR SPECTROMETERS10RR008389 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI VEDEJS, EDWIN · 1993 to 1993
–
CONSOLE UPGRADES FOR NMR FACILITYS10RR008438 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI MARKLEY, JOHN L · 1993 to 1993
–
NCRR NIH HHS S10 RR008389NCRR NIH HHS S10 RR008438NCRR NIH HHS S10 RR029220NIGMS NIH HHS P41 GM103399NIH HHS S10 OD020022
6 · The paper itself

Abstract

Transition metal-catalyzed nitrene transfer is a powerful method for incorporating new CN bonds into relatively unfunctionalized scaffolds. In this communication, we report the first examples of site- and chemoselective CH bond amination reactions in aqueous media. The unexpected ability to employ water as the solvent in these reactions is advantageous in that it eliminates toxic solvent use and enables reactions to be run at increased concentrations with lower oxidant loadings. Using water as the reaction medium has potential to expand the scope of nitrene transfer to encompass a variety of biomolecules and highly polar substrates, as well as enable pH control over the site-selectivity of CH bond amination.

Indexed as

AminationCarbonCatalysisHydrogenNitrogenSilverTransition ElementsWaterCarbonHydrogenNitrogenSilverTransition ElementsWaterAminesCH aminationNitrene transfer in waterSilver catalysis

Identifiers

PMID29681485
PMCPMC6657797

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.