ReviewInternational review of neurobiology2018
Expectancy Modulation of Opioid Neurotransmission.
Review in International review of neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03934138 (Does the Subject's Understanding of Underlying Placebo Mechanisms Compensate for the Loss of Efficacy Associated With the Disclosure of the Use of a Placebo), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Does the Subject's Understanding of Underlying Placebo Mechanisms Compensate for the Loss of Efficacy Associated With the Disclosure of the Use of a Placebo
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Placebo and nocebo effects and mechanisms associated with pharmacological interventions: an umbrella review.BMJ open · 2023Pooled it
- Article
- Neuropsychological mechanisms of observational learning in human placebo effects.Psychopharmacology · 2025Review
- Convergent state-control of endogenous opioid analgesia.bioRxiv : the preprint server for biology · 2025Article
- Engaging endogenous opioid circuits in pain affective processes.Journal of neuroscience research · 2022Review
- Effective Oriental Magic for Analgesia: Acupuncture.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Population-specific genetic background for the OPRM1 variant rs1799971 (118A>G): implications for genomic medicine and functional analysis.Molecular psychiatry · 2021Article
- Neuroinflammation, Pain and Depression: An Overview of the Main Findings.Frontiers in psychology · 2020Review
- Expectation effects on brain dopamine responses to methylphenidate in cocaine use disorder.Translational psychiatry · 2019Article
- Untangling the complexity of opioid receptor function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Review
- Preface: The Fascinating Mechanisms and Implications of the Placebo Effect.International review of neurobiology · 2018Article
- The Contribution of Endogenous Modulatory Systems to TMS- and tDCS-Induced Analgesia: Evidence from PET Studies.Pain research & management · 2018Review
- Optimizing Placebo and Minimizing Nocebo to Reduce Pain, Catastrophizing, and Opioid Use: A Review of the Science and an Evidence-Informed Clinical Toolkit.International review of neurobiology · 2018Review
- Positron emission tomography imaging of endogenous mu-opioid mechanisms during pain and migraine.Pain reportsReview
- A discursive exploration of public perspectives on placebos and their effects.Health psychology openArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Expectancies are powerful modulators of cognitive and emotional experiences, as well as the neurobiological responses linked to these processes. In medicine, placebo effects are a clear example of how expectancies activate opioid neurotransmission in a treatment context, leading to the experience of analgesia and the improvement of emotional states, among other symptoms. Molecular neuroimaging techniques using positron emission tomography (PET) and the selective μ-opioid receptor tracer [
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.