Evidence map›Paper›PMID 29681320›Full record

ReviewInternational review of neurobiology2018

Placebo Analgesia in Rodents: Current and Future Research.

Asaf Keller, Titilola Akintola, Luana Colloca

Abstract readReview
In one paragraph

Review in International review of neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. A new module in the drug development process: preclinical multi-center randomized controlled trial of R-ketamine on alcohol relapse.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  4. Article
  5. Convergent state-control of endogenous opioid analgesia.bioRxiv : the preprint server for biology · 2025
    Article
  6. Reverse-engineering placebo analgesia.Current biology : CB · 2024
    Article
  7. Article
  8. Article
  9. Placebo: a brief updated review.Naunyn-Schmiedeberg's archives of pharmacology · 2022
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Brain circuits for pain and its treatment.Science translational medicine · 2021
    Review
  16. Article
  17. Article
  18. Article
  19. The Placebo Effect in Pain Therapies.Annual review of pharmacology and toxicology · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Asaf KellerProgram in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, United States; Center to Advance Chronic Pain Research, University of Maryland, Baltimore, MD, United States. Electronic address: akeller@som.umaryland.edu.
Titilola AkintolaProgram in Toxicology, University of Maryland School of Medicine, Baltimore, MD, United States; University of Maryland School of Nursing, Baltimore, MD, United States.
Luana CollocaCenter to Advance Chronic Pain Research, University of Maryland, Baltimore, MD, United States; University of Maryland School of Nursing, Baltimore, MD, United States.

Funding

Parabrachial role in chronic painR01NS099245 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KELLER, ASAF, MASRI, RADI · 2017 to 2021
$2.2M
Chronic orofacial pain: genetics, cognitive-emotional factors, and endogenous modulatory systemsR01DE025946 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI COLLOCA, LUANA · 2016 to 2019
$2.1M
NIDCR NIH HHS R01 DE025946NINDS NIH HHS R01 NS099245
6 · The paper itself

Abstract

The investigation of placebo effects in animal pain models has received less attention than human research. This may be related to a number of difficulties, including the fact that animals lack the ability to use language and establish expectancies verbally, that animals cannot report and rate the extent to which they experience pain, and the inadequacy of current models of pain. Here, we describe the relatively small number of studies that have been published, communicating the opportunities and excitement of this research. We critically discuss pitfalls and limitations with the hope that this will advance future animal placebo-related research.

Indexed as

AnalgesiaConditioning, ClassicalPlacebo EffectAcute PainAnimalsChronic PainMiceRatsAcute painChronic painCompensatory responsesEvolutionLearningPharmacological conditioning

Identifiers

PMID29681320
PMCPMC5918296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.