Evidence map›Paper›PMID 29681015›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2018

Cold therapy to prevent paclitaxel-induced peripheral neuropathy.

Claire Griffiths, Nancy Kwon, Jennifer L Beaumont, Judith A Paice

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04558034 (The Use of Cryotherapy to Prevent Paclitaxel-induced Peripheral Neuropathy and Nail Changes in Women With Breast Cancer), which is not on this map. Cited by 28 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04558034 naterminatednot on this mapstarted 2020, after this paper: background citation

The Use of Cryotherapy to Prevent Paclitaxel-induced Peripheral Neuropathy and Nail Changes in Women With Breast Cancer

TypeinterventionalSponsorParkview HealthRan2020 to 2021Enrolled14ConditionsCryotherapy Effect, Peripheral Neuropathy, Nail ToxicityArmscryotherapy
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Pooled it
  5. Trial
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  8. Cooling the language on cryotherapy as an effective intervention to prevent or mitigate chemotherapy-induced peripheral neuropathy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  9. Article
  10. Regional limb cooling for the prevention of chemotherapy-induced toxicities: a narrative review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Claire GriffithsDepartment of Hospital Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Nancy KwonColumbia University, New York, NY, USA.
Jennifer L BeaumontDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Judith A PaiceDivision of Hematology-Oncology, Feinberg School of Medicine, Northwestern University, 676 N. St. Clair Street, Suite 850, Chicago, IL, 60611, USA. j-paice@northwestern.edu.ORCID http://orcid.org/0000-0001-7534-1756
Northwestern University · USColumbia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis case-control study was designed to assess the efficacy of cryotherapy to prevent paclitaxel-induced painful peripheral neuropathy in women with breast cancer.

methodsParticipants served as their own paired control, with randomization of the cooled glove/sock to either the dominant or the non-dominant hand/foot, worn for 15 min prior to, during, and 15 min after completion of the paclitaxel infusion. Outcome measures included the Neuropathic Pain Symptom Inventory, the Brief Pain Inventory, and quantitative sensory testing. Data were measured at each of six time points-baseline, post-treatment (approximately 2 weeks after the last paclitaxel infusion), and at the first, fifth, ninth, and final weekly paclitaxel treatments.

resultsOf 29 randomized participants, 20 (69%) received at least one cryotherapy treatment, and 11 (38%) received all four cryotherapy treatments. Ten (34%) participants could not tolerate the cryotherapy, and six (21%) declined further participation at some point during the trial. Only seven participants (24%) were available for the final post-chemotherapy QST and questionnaires. There were no significant differences in measures of neuropathy or pain between treated and untreated hands or feet.

conclusionsStrategies to prevent painful peripheral neuropathy are urgently needed. In this current trial, dropout due to discomfort precluded adequate power to fully understand the potential benefits of cryotherapy. Much more research is needed to discover safe and effective preventive strategies that can be easily implemented within busy infusion centers.

Indexed as

CryotherapyAdultAgedBreast NeoplasmsFemaleHumansHypothermia, InducedMiddle AgedNeuralgiaPaclitaxelPeripheral Nervous System DiseasesSurveys and QuestionnairesTreatment OutcomePaclitaxelChemotherapyCold therapyPaclitaxelPeripheral neuropathyTaxane

Identifiers

PMID29681015
OpenAlexW2800893360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.