ArticleMikrochimica acta2018
A signal-on ratiometric fluorometric heparin assay based on the direct interaction between amino-modified carbon dots and DNA.
Article in Mikrochimica acta, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 30 citations in OpenAlex.
- Advances in Carbon Dot-Based Ratiometric Fluorescent Probes for Environmental Contaminant Detection: A Review.Micromachines · 2024Review
- Ratiometric Fluorescent Biosensor Based on Forster Resonance Energy Transfer between Carbon Dots and Acridine Orange for miRNA Analysis.ACS omega · 2021Article
- A simple fluorescence assay for trypsin through a protamine-induced carbon quantum dot-quenching aggregation platform.RSC advances · 2020Article
- Fluorescence sensing of tyrosinase activity based on amine rich carbon dots through direct interaction in a homogeneous system: detection mechanism and application.RSC advances · 2019Article
- Insight into the DNA adsorption on nitrogen-doped positive carbon dots.RSC advances · 2019Article
- A colorimetric heparin assay based on the inhibition of the oxidase mimicking activity of cerium oxide nanoparticles.Mikrochimica acta · 2019Article
- Optical, electrochemical and catalytic methods for in-vitro diagnosis using carbonaceous nanoparticles: a review.Mikrochimica acta · 2019Review
- A ratiometric fluorometric heparin assay based on the use of CdTe and polyethyleneimine-coated carbon quantum dots.Mikrochimica acta · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Amino-modified carbon dots (C-dots) with positively charged surface were prepared. They display strong blue fluorescence and are shown to act as quenchers of the green fluorescence of FAM-labeled ssDNA such as the F-probe used in this work that was immobilized on the C-dots. On the addition of highly negatively charged heparin (Hep), it will interact with the C-dots and displace the F-probe from C-dots. Once the F-probe is displaced by Hep, its green fluorescence is restored. The intrinsic blue fluorescence of the C-dots remains stable after addition of Hep. Thus, a signal-on ratiometric fluorometric assay was developed for the ultra-sensitive detection of Hep. The underlying mechanisms of quenching and recovery are discussed. Under optimized conditions, the recovery of the ratiometric fluorescence of the system composed of C-dots and quenched F-probe is proportional to the Hep concentration in the range of 0.01-2.0 μg·mL
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